INT284089

Context Info Confidence 0.27 First Reported 2008 Last Reported 2008 Negated 1 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.73 Pain Relevance 0.61

plasma membrane (NTRK2, SERPINE1) endosome (NTRK2) extracellular space (SERPINE1) extracellular region (SERPINE1)

NTRK2 (Homo sapiens) SERPINE1 (Homo sapiens)

Pain Link Frequency Relevance Heat bDMF 21 100.00 depression 1 60.60 long-term potentiation 1 55.00 Migraine 1 41.76 Inflammatory response 1 5.00 Neuropeptide 1 5.00

Disease Link Frequency Relevance Heat Disease 126 95.32 Death 1 83.76 Diabetes Mellitus 15 63.68 Depression 1 60.60 Cardiovascular Disease 33 46.88 Headache 1 41.76 Aging 11 5.00 Neurodegenerative Disease 6 5.00 Stroke 4 5.00 Hypoxia 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Therefore, due to an increased level of PAI-1, mature BDNF could not be produced, which in turn could not bind to TrkB.

TrkB Neg (not) Binding (bind) of PAI-1 associated with bdmf

1) Confidence 0.27 Published 2008 Journal Genome Biol Section Body Doc Link PMC2760875 Disease Relevance 0.73 Pain Relevance 0.61

General Comments

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