INT284108

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.48
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (NTRK2) plasma membrane (NTRK2)
Anatomy Link Frequency
neuronal 2
NTRK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
bDMF 42 99.16 Very High Very High Very High
depression 2 67.64 Quite High
long-term potentiation 2 62.04 Quite High
Migraine 2 48.80 Quite Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Neuropeptide 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 252 99.68 Very High Very High Very High
Death 2 88.96 High High
Diabetes Mellitus 30 70.72 Quite High
Depression 2 67.64 Quite High
Cardiovascular Disease 66 53.92 Quite High
Headache 2 48.80 Quite Low
Aging 22 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 12 5.00 Very Low Very Low Very Low
Stroke 8 5.00 Very Low Very Low Very Low
Hypoxia 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, the expression levels of TrkB and PAI-1 were elevated in the AD samples.
Positive_regulation (elevated) of Gene_expression (expression) of TrkB associated with disease
1) Confidence 0.43 Published 2008 Journal Genome Biol Section Body Doc Link PMC2760875 Disease Relevance 0.75 Pain Relevance 0.58
By this reasoning, it can be concluded that high levels of TrkB and PAI-1 imply decreased levels of BDNF, which is detrimental for the survival of neuronal populations.
Positive_regulation (levels) of Gene_expression (levels) of TrkB in neuronal associated with bdmf
2) Confidence 0.40 Published 2008 Journal Genome Biol Section Body Doc Link PMC2760875 Disease Relevance 0.73 Pain Relevance 0.57

General Comments

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