INT284117

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 3.01
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Epcam)
Anatomy Link Frequency
body 1
bile duct epithelium 1
Epcam (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 4 99.84 Very High Very High Very High
abdominal pain 6 84.96 Quite High
Pain 5 54.96 Quite High
nud 4 25.80 Quite Low
withdrawal 5 25.32 Quite Low
cytokine 5 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 2 99.86 Very High Very High Very High
Pressure And Volume Under Development 68 98.78 Very High Very High Very High
Malignant Neoplastic Disease 23 98.62 Very High Very High Very High
Cancer 114 96.26 Very High Very High Very High
Solid Tumor 1 91.60 High High
Disease Progression 1 90.04 High High
Multiple Organ Failure 1 87.84 High High
Hepatotoxicity 2 87.60 High High
Toxicity 16 86.32 High High
Abdominal Pain 6 84.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-receptor I-, IIa- and III-positive accessory cells via its functional Fc domain.13 The simultaneous recruitment and activation of different immune effector cells at the tumor site leads to improved tumor-cell elimination by different immunologic killing mechanisms.14 EpCAM is expressed in the majority of epithelial cancers, making it an attractive target for antibody therapy.15 Tumor cells in malignant effusions have been shown to express EpCAM in 70–100% of those cases that commonly cause malignant ascites, e.g., breast, ovarian, gastric and colorectal cancer.16–18 EpCAM is also expressed on cells of normal epithelial tissues.15 However, normal EpCAM-positive tissue is assumed to be inaccessible to intact antibodies in vivo because of its protection by the basal lamina.19 In contrast, EpCAM in solid tumors is expected to be accessible for binding with intact antibodies after passage through the leaky tumor mosaic vessels or in body fluids such as ascites or pleural effusions.
Protein_catabolism (expressed) of EpCAM in body associated with pleural effusion, pressure and volume under development, malignant neoplastic disease, cancer, colon cancer and solid tumor
1) Confidence 0.43 Published 2010 Journal International Journal of Cancer. Journal International du Cancer Section Body Doc Link PMC2958458 Disease Relevance 1.54 Pain Relevance 0.05
It is well documented that EpCAM is not expressed on adult hepatocytes but is detectable on bile duct epithelium (De Boer et al 1999; Schmelzer and Reid 2008).
Protein_catabolism (detectable) of EpCAM in bile duct epithelium associated with bile
2) Confidence 0.16 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761172 Disease Relevance 1.46 Pain Relevance 0.25

General Comments

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