INT284126

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Context Info
Confidence 0.37
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Cyp2b3)
Anatomy Link Frequency
hepatocytes 1
Cyp2b3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
sSRI 1 60.52 Quite High
tricyclic antidepressant 1 58.76 Quite High
carbamazepine 1 37.92 Quite Low
headache 6 5.00 Very Low Very Low Very Low
Dopamine 5 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
gABA 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
psychological dependence 1 5.00 Very Low Very Low Very Low
Intracerebroventricular 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 1 45.80 Quite Low
Cirrhosis 1 16.44 Low Low
Chronic Renal Failure 1 8.96 Low Low
Hypersomnia 87 5.00 Very Low Very Low Very Low
Sleep Disorders 53 5.00 Very Low Very Low Very Low
Apnoea 44 5.00 Very Low Very Low Very Low
Headache 6 5.00 Very Low Very Low Very Low
Anxiety 5 5.00 Very Low Very Low Very Low
Exanthema 5 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Modafinil also has been shown to cause a modest induction of CYP3A4, CYP2B6, and CYP1A2 in human hepatocytes (Robertson et al 2000).
Positive_regulation (induction) of CYP2B6 in hepatocytes
1) Confidence 0.37 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761173 Disease Relevance 0 Pain Relevance 0.06

General Comments

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