INT284141

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Context Info
Confidence 0.05
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.10
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (PAH) aging (EDNRA) signal transducer activity (EDNRA)
cell proliferation (EDNRA) cytosol (PAH) signal transduction (EDNRA)
Anatomy Link Frequency
plasma 1
EDNRA (Homo sapiens)
PAH (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 41 81.52 Quite High
Bioavailability 1 29.60 Quite Low
cytokine 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Kinase C 2 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Bile 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Hypertension 65 100.00 Very High Very High Very High
Disease 12 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 10 5.00 Very Low Very Low Very Low
Congenital Anomalies 4 5.00 Very Low Very Low Very Low
Dyspnea 4 5.00 Very Low Very Low Very Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 3 5.00 Very Low Very Low Very Low
Stress 3 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 3 5.00 Very Low Very Low Very Low
Natriuresis 2 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At therapeutically relevant plasma concentrations in PAH, ambrisentan has higher receptor occupancy with ETA (> 90%), than ETB (<10%).
ETA Binding (occupancy) of PAH in plasma associated with pulmonary hypertension
1) Confidence 0.05 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761178 Disease Relevance 0.10 Pain Relevance 0.09

General Comments

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