INT28416

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Context Info
Confidence 0.46
First Reported 1989
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 1.19
Pain Relevance 1.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Cth) nucleus (Cth) cellular_component (Cth)
cellular amino acid metabolic process (Cth) cytoplasm (Cth)
Anatomy Link Frequency
neurons 1
bladders 1
Cth (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hyperalgesia 4 98.28 Very High Very High Very High
Paracetamol 5 96.64 Very High Very High Very High
Pyramidal cell 8 88.28 High High
lidocaine 2 86.56 High High
spinal dorsal horn 1 86.08 High High
gABA 8 86.04 High High
antagonist 2 85.12 High High
Glutamate receptor 2 84.64 Quite High
Inflammation 2 74.92 Quite High
potassium channel 1 65.84 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 4 98.28 Very High Very High Very High
Hypoxia 6 97.04 Very High Very High Very High
Necrosis 2 81.68 Quite High
Nociception 3 79.32 Quite High
INFLAMMATION 2 74.92 Quite High
Injury 1 63.76 Quite High
Cyst 2 58.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Propargylglycine, an inhibitor of cystathionase, abolished the hepatoprotective effects of cystathionine, although it could not affect the action of cysteine.
Negative_regulation (inhibitor) of cystathionase
1) Confidence 0.46 Published 1989 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2760849 Disease Relevance 0.28 Pain Relevance 0.40
An inhibitor of cystathionine gamma-lyase (CSE), DL-propargylglycine (PPG, 200 micromol/L) inhibited CBA in male rats and shifted FCCB to the right and downward.
Negative_regulation (inhibitor) of cystathionine gamma-lyase
2) Confidence 0.43 Published 2007 Journal Chin. Med. J. Section Body Doc Link 17711741 Disease Relevance 0 Pain Relevance 0
L-Cysteine, an endogenous source for H(2)S, given i.pl., also elicited hyperalgesia, an effect being abolished by DL-propargylglycine (PPG) and beta-cyanoalanine (BCA), inhibitors of cystathionine-gamma-lyase, a H(2)S synthesizing enzyme.
Negative_regulation (inhibitors) of cystathionine-gamma-lyase associated with hyperalgesia
3) Confidence 0.21 Published 2007 Journal Pain Section Abstract Doc Link 17346888 Disease Relevance 0.66 Pain Relevance 0.47
In neurons intracellularly perfused for 1-2 hr with F(-) as the major anion and no ATP, the hIPSP (and the corresponding current, hIPSC) evoked by HFS was blocked, whereas neither the late depolarization nor its underlying current was attenuated.
Negative_regulation (blocked) of hIPSP in neurons
4) Confidence 0.11 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 10531429 Disease Relevance 0 Pain Relevance 0.33
The attenuation of the [K(+)](o) transient was closely paralleled by a suppression of the HFS-evoked depolarization but not of the hIPSP.
Negative_regulation (suppression) of hIPSP
5) Confidence 0.10 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 10531429 Disease Relevance 0 Pain Relevance 0.40
H2S was produced by trout bladders, and its production was sensitive to inhibitors of cystathionine beta-synthase and cystathionine gamma-lyase.
Negative_regulation (inhibitors) of cystathionine gamma-lyase in bladders
6) Confidence 0.02 Published 2006 Journal J. Exp. Biol. Section Abstract Doc Link 16888071 Disease Relevance 0.25 Pain Relevance 0.03

General Comments

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