INT28417

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Context Info
Confidence 0.03
First Reported 1989
Last Reported 1989
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.56

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lipid binding (Ltc4s) nuclear envelope (Ltc4s) lyase activity (Ltc4s)
endoplasmic reticulum (Ltc4s) nucleus (Ltc4s)
Anatomy Link Frequency
mesenteric vein 3
vena cava 1
Ltc4s (Rattus norvegicus)
Pain Link Frequency Relevance Heat
noradrenaline 6 99.68 Very High Very High Very High
Clonidine 2 94.72 High High
Potency 2 87.48 High High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The gingerols alone relaxed the muscle transiently and then augmented the response to PGF2 alpha, PGE2, PGI2-Na, and TRK-100, but suppressed the response to PGD2, U-46619, LTC4, LTD4, NA and PhE. (+/-)-[6]-Gingerol also potentiated the PGF2 alpha-induced contraction in longitudinal segments of rat mesenteric vein and vena cava, but inhibited it in circular segments of rat aorta and longitudinal segments of mouse mesenteric arteries.
Negative_regulation (suppressed) of Regulation (response) of LTC4 in mesenteric vein associated with noradrenaline
1) Confidence 0.03 Published 1989 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 2761127 Disease Relevance 0 Pain Relevance 0.28
The gingerols alone relaxed the muscle transiently and then augmented the response to PGF2 alpha, PGE2, PGI2-Na, and TRK-100, but suppressed the response to PGD2, U-46619, LTC4, LTD4, NA and PhE. (+/-)-[6]-Gingerol also potentiated the PGF2 alpha-induced contraction in longitudinal segments of rat mesenteric vein and vena cava, but inhibited it in circular segments of rat aorta and longitudinal segments of mouse mesenteric arteries.
Negative_regulation (suppressed) of in vena cava Regulation (response) of LTC4 in mesenteric vein associated with noradrenaline
2) Confidence 0.01 Published 1989 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 2761127 Disease Relevance 0 Pain Relevance 0.28

General Comments

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