INT2842

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Context Info
Confidence 0.50
First Reported 1979
Last Reported 2010
Negated 1
Speculated 0
Reported most in Title
Documents 3
Total Number 3
Disease Relevance 0
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Prl)
Anatomy Link Frequency
pituitary 2
Prl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fluoxetine 4 100.00 Very High Very High Very High
Enkephalin 1 99.22 Very High Very High Very High
dopamine receptor 1 88.12 High High
agonist 1 85.96 High High
Serotonin 1 76.32 Quite High
Disease Link Frequency Relevance Heat
Galactorrhea 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that: the reduction in serotoninergic activity after PCPA administration did not modify serum PRL concentrations; the stimulatory effect of 5-HTP on PRL secretion was not observed before day 16; the effects of 5-HTP or 5-HTP and fluoxetine were similar in intact and orchidectomized males; a significant increase in PRL secretion took place after 8-OH-DPAT administration; the duration of the stimulatory effect of 5-HTP increased after alpha-diol treatment; and pituitary PRL content increased after 5-HTP injection in intact males and decreased in castrated males treated with testosterone or alpha-diol.
Positive_regulation (increased) of PRL Neg (not) Binding (concentrations) of in pituitary associated with fluoxetine
1) Confidence 0.50 Published 1994 Journal Eur. J. Endocrinol. Section Abstract Doc Link 7524955 Disease Relevance 0 Pain Relevance 0.26
[Inhibitory effects of indomethacin on prolactin liberation induced with peptides with opium-like activity].
Positive_regulation (induced) of prolactin Binding (liberation) of associated with enkephalin
2) Confidence 0.42 Published 1979 Journal Boll. Soc. Ital. Biol. Sper. Section Title Doc Link 548065 Disease Relevance 0 Pain Relevance 0.10
Genetic associations of prolactin increase in olanzapine/fluoxetine combination-treated patients.
Positive_regulation (increase) of prolactin Binding (associations) of associated with fluoxetine
3) Confidence 0.18 Published 2010 Journal Psychiatry Res Section Title Doc Link 19896213 Disease Relevance 0 Pain Relevance 0.23

General Comments

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