INT284202

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Context Info
Confidence 0.09
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.83
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
hinge 1
Eclc (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 38 86.28 High High
chemokine 18 5.00 Very Low Very Low Very Low
potassium channel 4 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 114 95.72 Very High Very High Very High
Disease Progression 2 64.80 Quite High
Immunodeficiency 4 63.36 Quite High
Sprains And Strains 8 61.16 Quite High
Opportunistic Infections 2 56.64 Quite High
Disease 8 56.52 Quite High
Hepatotoxicity 2 55.60 Quite High
Viremia 2 37.40 Quite Low
Infection 12 15.76 Low Low
Congenital Anomalies 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The drug binds to the same pocket as maraviroc within the transmembrane region of CCR5, but also shows interactions with the ECL2 hinge region.
ECL2 Binding (interactions) of in hinge
1) Confidence 0.09 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761192 Disease Relevance 0.38 Pain Relevance 0.04
The V3 loop, on the other hand, mediates interactions with the second extracellular loop (ECL2) of CCR5 or CXCR4 and is the principle determinant of coreceptor specificity.
ECL2 Spec (determinant) Binding (interactions) of
2) Confidence 0.07 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761192 Disease Relevance 0.45 Pain Relevance 0.11

General Comments

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