INT284217

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.27
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ccr5) signal transduction (Ccr5) plasma membrane (Ccr5)
cell-cell signaling (Ccr5) cytoplasm (Ccr5) signal transducer activity (Ccr5)
Anatomy Link Frequency
cavity 1
Ccr5 (Mus musculus)
Hivan1 (Mus musculus)
Pain Link Frequency Relevance Heat
potassium channel 2 87.84 High High
chemokine 9 58.48 Quite High
Inflammation 1 56.84 Quite High
antagonist 19 47.36 Quite Low
agonist 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 57 100.00 Very High Very High Very High
INFLAMMATION 1 56.84 Quite High
Infection 6 5.00 Very Low Very Low Very Low
Sprains And Strains 4 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Immunodeficiency 2 5.00 Very Low Very Low Very Low
Congenital Anomalies 2 5.00 Very Low Very Low Very Low
Hepatotoxicity 1 5.00 Very Low Very Low Very Low
Vomiting 1 5.00 Very Low Very Low Very Low
Viremia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Insertion of these small molecules into a cavity located within the transmembrane helices disrupts the geometry of a multi-point interaction between CCR5 and HIV-1 gp120 (Dragic et al 2000; Tsamis et al 2003; Watson et al 2005; Seibert et al 2006).
CCR5 Binding (interaction) of HIV in cavity associated with acquired immune deficiency syndrome or hiv infection
1) Confidence 0.01 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761192 Disease Relevance 0.27 Pain Relevance 0.14

General Comments

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