INT284227

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Context Info
Confidence 0.73
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.43
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (SYCP3) cell cycle (SYCP3) DNA binding (SYCP3)
cell division (SYCP3)
SYCP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 21 98.40 Very High Very High Very High
antagonist 60 95.36 Very High Very High Very High
potassium channel 4 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
drug abuse 1 5.00 Very Low Very Low Very Low
Paracetamol 1 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
peripheral neuropathy 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 208 94.00 High High
Disease 10 91.28 High High
Infection 32 83.60 Quite High
Syndrome 2 50.88 Quite High
Immunodeficiency 5 50.52 Quite High
Disease Progression 8 44.88 Quite Low
Severe Combined Immunodeficiency 2 18.52 Low Low
Sarcoma 1 9.88 Low Low
Cytomegalovirus Infection 1 9.00 Low Low
Pneumocystis Carinii Infection 1 8.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, results from most resistance studies, thus far, suggest that this switch to CXCR4 usage is in fact not observed frequently and instead viruses usually acquire resistance to these drugs by using a drug-bound conformation of the CCR5 coreceptor.
Localization (conformation) of coreceptor
1) Confidence 0.73 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761192 Disease Relevance 0.21 Pain Relevance 0.05
Viruses that use the CCR5 or the CXCR4 coreceptors alone are called R5 or X4 viruses respectively, while those that can use both are referred to as R5X4 viruses.
Localization (use) of coreceptor
2) Confidence 0.73 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761192 Disease Relevance 0.57 Pain Relevance 0.05
Variants may exclusively use the CCR5 coreceptor (CCR5-tropic or R5 viruses) or exclusively use the CXCR4 coreceptor (CXCR4-tropic or X4 viruses).
Localization (use) of coreceptor
3) Confidence 0.73 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012555 Disease Relevance 0.65 Pain Relevance 0

General Comments

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