INT284228

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.29
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (ITIH4) plasma membrane (ITIH4) cytoplasm (ITIH4)
ITIH4 (Homo sapiens)
Eclc (Mus musculus)
Pain Link Frequency Relevance Heat
potassium channel 2 81.36 Quite High
chemokine 9 52.00 Quite High
Inflammation 1 50.36 Quite High
antagonist 19 40.88 Quite Low
agonist 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 57 94.80 High High
INFLAMMATION 1 50.36 Quite High
Infection 6 5.00 Very Low Very Low Very Low
Sprains And Strains 4 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Immunodeficiency 2 5.00 Very Low Very Low Very Low
Congenital Anomalies 2 5.00 Very Low Very Low Very Low
Hepatotoxicity 1 5.00 Very Low Very Low Very Low
Vomiting 1 5.00 Very Low Very Low Very Low
Viremia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This multi-point interaction is formed by binding of the second extracellular loop (ECL-2) to elements of the gp120 V3 region and the tyrosine-sulfated N-terminus (Tyr-Nt) of CCR5 binding the more conserved bridging sheet that forms between the C1, C2, and C4 domains upon CD4 binding (Cormier and Dragic 2002; Huang et al 2007).


gp120 Binding (binding) of ECL-2
1) Confidence 0.02 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761192 Disease Relevance 0.29 Pain Relevance 0.12

General Comments

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