INT28425

Context Info Confidence 0.28 First Reported 1989 Last Reported 2007 Negated 0 Speculated 0 Reported most in Abstract Documents 4 Total Number 4 Disease Relevance 2.07 Pain Relevance 1.53

isomerase activity (Ptgds) transport (Ptgds) Golgi apparatus (Ptgds) endoplasmic reticulum (Ptgds) lipid metabolic process (Ptgds) cytoplasm (Ptgds)

Anatomy Link Frequency neuronal 1 mesenteric vein 1 vena cava 1 Ptgds (Mus musculus)

Pain Link Frequency Relevance Heat corticosteroid 2 99.96 cINOD 7 99.56 Inflammation 78 99.10 noradrenaline 6 99.08 Clonidine 2 94.12 aspirin 1 93.76 Potency 2 86.88 dexamethasone 1 80.24 Inflammatory stimuli 1 63.76 Inflammatory response 2 48.88

Disease Link Frequency Relevance Heat Injury 4 99.32 INFLAMMATION 85 99.10 Aging 1 96.96 Disease 3 96.28 Targeted Disruption 2 91.68 Alzheimer's Dementia 1 90.32 Motor Neuron Diseases 1 85.84 Stroke 1 83.60 Neurological Disease 3 78.16 Hypersensitivity 2 67.60

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The gingerols alone relaxed the muscle transiently and then augmented the response to PGF2 alpha, PGE2, PGI2-Na, and TRK-100, but suppressed the response to PGD2, U-46619, LTC4, LTD4, NA and PhE. (+/-)-[6]-Gingerol also potentiated the PGF2 alpha-induced contraction in longitudinal segments of rat mesenteric vein and vena cava, but inhibited it in circular segments of rat aorta and longitudinal segments of mouse mesenteric arteries.

Regulation (response) of PGD2 in mesenteric vein associated with noradrenaline

1) Confidence 0.28 Published 1989 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 2761127 Disease Relevance 0 Pain Relevance 0.28

How do commonly used anti-inflammatory agents, such as NSAIDs and corticosteroids, affect PGD2 levels?

Regulation (affect) of PGD2 associated with corticosteroid, inflammation and cinod

2) Confidence 0.25 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206389 Disease Relevance 0.65 Pain Relevance 0.62

COX-mediated neuronal injury is presumed be due to downstream effects of one or more prostaglandin products including PGE2, PGD2, PGF2alpha, PGI2 (prostacylin) and TXA2 (thromboxane) that effect cellular changes through activation of specific prostaglandin receptor subtypes and second messenger systems.

Regulation (effects) of PGD2 in neuronal associated with injury

3) Confidence 0.21 Published 2007 Journal J. Mol. Neurosci. Section Abstract Doc Link 17901552 Disease Relevance 1.42 Pain Relevance 0.35

The gingerols alone relaxed the muscle transiently and then augmented the response to PGF2 alpha, PGE2, PGI2-Na, and TRK-100, but suppressed the response to PGD2, U-46619, LTC4, LTD4, NA and PhE. (+/-)-[6]-Gingerol also potentiated the PGF2 alpha-induced contraction in longitudinal segments of rat mesenteric vein and vena cava, but inhibited it in circular segments of rat aorta and longitudinal segments of mouse mesenteric arteries.

Regulation (response) of PGD2 in vena cava associated with noradrenaline

4) Confidence 0.09 Published 1989 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 2761127 Disease Relevance 0 Pain Relevance 0.28

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