INT28425

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Context Info
Confidence 0.28
First Reported 1989
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.07
Pain Relevance 1.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Ptgds) transport (Ptgds) Golgi apparatus (Ptgds)
endoplasmic reticulum (Ptgds) lipid metabolic process (Ptgds) cytoplasm (Ptgds)
Anatomy Link Frequency
neuronal 1
mesenteric vein 1
vena cava 1
Ptgds (Mus musculus)
Pain Link Frequency Relevance Heat
corticosteroid 2 99.96 Very High Very High Very High
cINOD 7 99.56 Very High Very High Very High
Inflammation 78 99.10 Very High Very High Very High
noradrenaline 6 99.08 Very High Very High Very High
Clonidine 2 94.12 High High
aspirin 1 93.76 High High
Potency 2 86.88 High High
dexamethasone 1 80.24 Quite High
Inflammatory stimuli 1 63.76 Quite High
Inflammatory response 2 48.88 Quite Low
Disease Link Frequency Relevance Heat
Injury 4 99.32 Very High Very High Very High
INFLAMMATION 85 99.10 Very High Very High Very High
Aging 1 96.96 Very High Very High Very High
Disease 3 96.28 Very High Very High Very High
Targeted Disruption 2 91.68 High High
Alzheimer's Dementia 1 90.32 High High
Motor Neuron Diseases 1 85.84 High High
Stroke 1 83.60 Quite High
Neurological Disease 3 78.16 Quite High
Hypersensitivity 2 67.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The gingerols alone relaxed the muscle transiently and then augmented the response to PGF2 alpha, PGE2, PGI2-Na, and TRK-100, but suppressed the response to PGD2, U-46619, LTC4, LTD4, NA and PhE. (+/-)-[6]-Gingerol also potentiated the PGF2 alpha-induced contraction in longitudinal segments of rat mesenteric vein and vena cava, but inhibited it in circular segments of rat aorta and longitudinal segments of mouse mesenteric arteries.
Regulation (response) of PGD2 in mesenteric vein associated with noradrenaline
1) Confidence 0.28 Published 1989 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 2761127 Disease Relevance 0 Pain Relevance 0.28
How do commonly used anti-inflammatory agents, such as NSAIDs and corticosteroids, affect PGD2 levels?
Regulation (affect) of PGD2 associated with corticosteroid, inflammation and cinod
2) Confidence 0.25 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206389 Disease Relevance 0.65 Pain Relevance 0.62
COX-mediated neuronal injury is presumed be due to downstream effects of one or more prostaglandin products including PGE2, PGD2, PGF2alpha, PGI2 (prostacylin) and TXA2 (thromboxane) that effect cellular changes through activation of specific prostaglandin receptor subtypes and second messenger systems.
Regulation (effects) of PGD2 in neuronal associated with injury
3) Confidence 0.21 Published 2007 Journal J. Mol. Neurosci. Section Abstract Doc Link 17901552 Disease Relevance 1.42 Pain Relevance 0.35
The gingerols alone relaxed the muscle transiently and then augmented the response to PGF2 alpha, PGE2, PGI2-Na, and TRK-100, but suppressed the response to PGD2, U-46619, LTC4, LTD4, NA and PhE. (+/-)-[6]-Gingerol also potentiated the PGF2 alpha-induced contraction in longitudinal segments of rat mesenteric vein and vena cava, but inhibited it in circular segments of rat aorta and longitudinal segments of mouse mesenteric arteries.
Regulation (response) of PGD2 in vena cava associated with noradrenaline
4) Confidence 0.09 Published 1989 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 2761127 Disease Relevance 0 Pain Relevance 0.28

General Comments

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