INT284274

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Context Info
Confidence 0.50
First Reported 2009
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 16
Disease Relevance 7.68
Pain Relevance 2.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
macrophages 6
astrocytes 2
brain white matter 1
poly 1
monocyte 1
Mir155 (Mus musculus)
Pain Link Frequency Relevance Heat
Multiple sclerosis 1106 100.00 Very High Very High Very High
cytokine 249 100.00 Very High Very High Very High
chemokine 43 100.00 Very High Very High Very High
Inflammatory response 106 99.96 Very High Very High Very High
Arthritis 158 98.90 Very High Very High Very High
Inflammation 360 98.70 Very High Very High Very High
Central nervous system 191 96.00 Very High Very High Very High
Inflammatory stimuli 7 87.56 High High
rheumatoid arthritis 156 71.12 Quite High
antagonist 15 67.84 Quite High
Disease Link Frequency Relevance Heat
Demyelinating Disease 1225 100.00 Very High Very High Very High
Myeloproliferative Disorder 22 99.84 Very High Very High Very High
INFLAMMATION 441 99.78 Very High Very High Very High
Cancer 87 99.48 Very High Very High Very High
Arthritis 154 98.90 Very High Very High Very High
Necrosis 24 97.76 Very High Very High Very High
Targeted Disruption 65 96.98 Very High Very High Very High
Lymphatic System Cancer 1 96.26 Very High Very High Very High
Central Nervous System Disease 189 96.00 Very High Very High Very High
Disease 532 95.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment of cultured mouse macrophages with LPS showed dose-dependent induction of miR-155 with more than 10-fold increase in miR-155 expression levels at a concentration of 100 ng/ml LPS after 18 h (Figure 1A).
Positive_regulation (induction) of miR-155 in macrophages
1) Confidence 0.50 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2761263 Disease Relevance 0.08 Pain Relevance 0
LPS-mediated induction of miR-155 in cultured mouse Raw264.7 macrophages
Positive_regulation (induction) of miR-155 in macrophages
2) Confidence 0.41 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2761263 Disease Relevance 0 Pain Relevance 0
Figure 1.LPS-mediated induction of miR-155 in cultured mouse Raw264.7 macrophages.
Positive_regulation (induction) of miR-155 in macrophages
3) Confidence 0.41 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2761263 Disease Relevance 0.05 Pain Relevance 0
In addition, miR-155 has been shown to regulate the production of cytokines, chemokines and transcription factors (6,7) and to be induced by endotoxins, such as bacterial lipopolysaccharide (LPS) (8–10).
Positive_regulation (induced) of miR-155 associated with chemokine and cytokine
4) Confidence 0.38 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2761263 Disease Relevance 0.38 Pain Relevance 0.20
Since miR-155 has previously been shown to be upregulated during macrophage activation (8–10) we first investigated the expression of miR-155 in murine Raw264.7 macrophage cells upon LPS stimulation.
Positive_regulation (upregulated) of miR-155 in macrophage
5) Confidence 0.33 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2761263 Disease Relevance 0.06 Pain Relevance 0
Treatment of cultured mouse macrophages with LPS showed dose-dependent induction of miR-155 with more than 10-fold increase in miR-155 expression levels at a concentration of 100 ng/ml LPS after 18 h (Figure 1A).
Positive_regulation (increase) of miR-155 in macrophages
6) Confidence 0.33 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2761263 Disease Relevance 0.08 Pain Relevance 0
TLR ligands that induced miR-155 also required myeloid differentiation factor 88 (MyD88) or the TIR-domain-containing adapter-inducing IFN-?
Positive_regulation (induced) of miR-155
7) Confidence 0.10 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 0.34 Pain Relevance 0.29
Another piece of the miR story with specific relevance to inflammatory arthritis emerged when O'Connell et al. [108] demonstrated that miR-155 was the only miR to be upregulated in monocyte cultures by either polyriboinosinic acid:polyribocytidylic acid [poly (I:C)], a synthetic ligand that activates the TLR pathway, and interferon-?
Positive_regulation (upregulated) of miR-155 in monocyte associated with inflammation and arthritis
8) Confidence 0.09 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 0.29 Pain Relevance 0.27
MiRNA profiling in isolated cells by laser capture microdissection from active and inactive MS lesions showed that the most prominently upregulated miRNAs in active MS lesions, miR-155, miR-650, miR-34a, and miR-326 were detected in both microdissected astrocytes and infiltrating immune cells [261].
Positive_regulation (upregulated) of miR-155 in astrocytes associated with multiple sclerosis
9) Confidence 0.08 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.93 Pain Relevance 0.45
Of these miRNAs, only miR-146a and miR-155 appear to be induced in multiple cell types.
Positive_regulation (induced) of miR-155
10) Confidence 0.08 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.43 Pain Relevance 0.11
Although Junker et al. have focused on only three upregulated miRNAs in active MS lesions (i.e., miR-155, miR-326, and miR-34a) and their common target CD47, other upregulated miRNAs, especially miR-146a and miR-34a deserve further mention.
Positive_regulation (upregulated) of miR-155 associated with multiple sclerosis
11) Confidence 0.07 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.93 Pain Relevance 0.33
Junker et al. found that three of the most upregulated miRNAs in active MS lesions, namely, miR-155, miR-326, and miR-34a, target CD47, which was one of the downregulated transcripts in the active lesions in comparison to normal brain white matter.
Positive_regulation (upregulated) of miR-155 in brain white matter associated with multiple sclerosis
12) Confidence 0.07 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.91 Pain Relevance 0.39
In macrophages and DCs, stimulation by TLRs ligands results in miR-155 induction via NF?
Positive_regulation (induction) of miR-155 in macrophages
13) Confidence 0.07 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.44 Pain Relevance 0.11
Under in vitro culture conditions, human astrocytes contained all 10 miRNA that were most strongly upregulated in active MS lesions, including miR-155, which is known to modulate immune responses in different ways but so far had not been assigned to CNS resident cells [104, 137, 271, 272].
Positive_regulation (upregulated) of miR-155 in astrocytes associated with multiple sclerosis and central nervous system
14) Confidence 0.07 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.80 Pain Relevance 0.41
during the inflammatory response. miR-155 is upregulated in murine macrophages by the synthetic triacylated lipopeptide Pam3CSK4, the synthetic double stranded RNA analog poly(I:C), LPS, and CpG oligonucleotides, suggesting that several TLR ligands can induce miR-155 expression and that miR-155 is involved in the regulation of both bacterial and viral innate immune responses [148].
Positive_regulation (upregulated) of miR-155 in poly associated with inflammatory response
15) Confidence 0.07 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.50 Pain Relevance 0.11
92 cluster, was shown to decrease the latency of lymphoma development in the c-myc transgenic setting (He et al., 2005), but there is little evidence that overexpression of a single miRNA is sufficient to induce cancer in a WT genetic setting. miR-155 was shown to induce oligoclonal expansion of pre–B/pro–B cells when expressed as a B cell–specific transgene (Costinean et al., 2006) and also induced an MPD using a similar experimental approach to ours (O’Connell et al., 2008); however, in neither case did miR-155–induced disease progress to acute leukemia.
Positive_regulation (induced) of miR-155 in B cell associated with myeloproliferative disorder, targeted disruption, leukemia, lymphatic system cancer, cancer and disease
16) Confidence 0.04 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 1.44 Pain Relevance 0

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