INT2843

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Context Info
Confidence 0.78
First Reported 1979
Last Reported 2010
Negated 0
Speculated 4
Reported most in Abstract
Documents 100
Total Number 107
Disease Relevance 62.01
Pain Relevance 14.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Epo) aging (Epo) extracellular region (Epo)
Anatomy Link Frequency
kidney 6
megakaryocytes 4
PNS 4
liver 4
central nervous system 3
Epo (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 586 100.00 Very High Very High Very High
cytokine 256 100.00 Very High Very High Very High
depression 5 100.00 Very High Very High Very High
intrathecal 1 99.98 Very High Very High Very High
Peripheral nervous system 54 99.96 Very High Very High Very High
Analgesic 7 99.92 Very High Very High Very High
antidepressant 1 99.90 Very High Very High Very High
Central nervous system 15 99.68 Very High Very High Very High
Inflammation 194 99.52 Very High Very High Very High
Pain 14 99.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 372 100.00 Very High Very High Very High
Erythremia 12 100.00 Very High Very High Very High
Depression 4 100.00 Very High Very High Very High
Renal Cancer 17 99.96 Very High Very High Very High
Appetite Loss 2 99.96 Very High Very High Very High
Hypoalbuminemia 1 99.92 Very High Very High Very High
Uremia 9 99.84 Very High Very High Very High
Erythrocytosis 18 99.82 Very High Very High Very High
Anaemia 401 99.80 Very High Very High Very High
Apoptosis 385 99.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has not been determined what effect ritodrine may have on EPO production.
Gene_expression (production) of EPO
1) Confidence 0.78 Published 1994 Journal Biochem. Med. Metab. Biol. Section Abstract Doc Link 7993659 Disease Relevance 0.19 Pain Relevance 0.18
Erythropoietin (EPO) is a hematopoietic factor, which is produced primarily by the adult kidney in response to tissue hypoxia.
Gene_expression (produced) of Erythropoietin in adult kidney associated with hypoxia
2) Confidence 0.78 Published 2007 Journal Auton Neurosci Section Abstract Doc Link 17306629 Disease Relevance 0.10 Pain Relevance 0.08
Erythropoietin (EPO) is a hematopoietic factor, which is produced primarily by the adult kidney in response to tissue hypoxia.
Gene_expression (produced) of EPO in adult kidney associated with hypoxia
3) Confidence 0.78 Published 2007 Journal Auton Neurosci Section Abstract Doc Link 17306629 Disease Relevance 0.10 Pain Relevance 0.08
There is strong evidence that EPO may also be synthesized in the brain and act as a neuroprotector or neuromodulator in the central nervous system.
Gene_expression (synthesized) of EPO in central nervous system associated with central nervous system
4) Confidence 0.78 Published 2007 Journal Auton Neurosci Section Abstract Doc Link 17306629 Disease Relevance 0.15 Pain Relevance 0.09
However, peripheral nervous system (PNS) EPO and EPO receptor expression has not been widely studied.
Gene_expression (expression) of EPO in PNS associated with peripheral nervous system
5) Confidence 0.78 Published 2010 Journal Brain Res. Section Abstract Doc Link 20361946 Disease Relevance 0.62 Pain Relevance 0.73
However, peripheral nervous system (PNS) EPO and EPO receptor expression has not been widely studied.
Gene_expression (expression) of EPO in PNS associated with peripheral nervous system
6) Confidence 0.78 Published 2010 Journal Brain Res. Section Abstract Doc Link 20361946 Disease Relevance 0.62 Pain Relevance 0.73
Recent data have suggested that EPO and EPO receptors are expressed in the central nervous system, where EPO exerts neuroprotective effects.
Gene_expression (expressed) of EPO in central nervous system associated with central nervous system
7) Confidence 0.78 Published 2010 Journal Brain Res. Section Abstract Doc Link 20361946 Disease Relevance 0.41 Pain Relevance 0.59
Recent data have suggested that EPO and EPO receptors are expressed in the central nervous system, where EPO exerts neuroprotective effects.
Gene_expression (expressed) of EPO in central nervous system associated with central nervous system
8) Confidence 0.78 Published 2010 Journal Brain Res. Section Abstract Doc Link 20361946 Disease Relevance 0.41 Pain Relevance 0.59
Erythropoietin-producing renal cell carcinoma arising from acquired cystic disease of the kidney.
Gene_expression (producing) of Erythropoietin in kidney associated with renal cancer and disease
9) Confidence 0.78 Published 1998 Journal Int. J. Urol. Section Title Doc Link 9781442 Disease Relevance 0.63 Pain Relevance 0.09
Pathologic examination revealed EPO-producing renal cell carcinoma.
Gene_expression (producing) of EPO associated with renal cancer
10) Confidence 0.78 Published 1998 Journal Int. J. Urol. Section Abstract Doc Link 9781442 Disease Relevance 0.61 Pain Relevance 0.09
Cultivated mature endothelial cells also express EPO and erythropoietin receptor (EPOR) and endothelial cell proliferation has been shown to be induced by EPO (Vogel et al., 1997).
Gene_expression (express) of EPO in endothelial cell
11) Confidence 0.77 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998786 Disease Relevance 0.46 Pain Relevance 0.04
Kupffer cells seem to be the site of erythropoietin production after hepatectomy [5].
Gene_expression (production) of erythropoietin in Kupffer cells
12) Confidence 0.77 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2917416 Disease Relevance 0.27 Pain Relevance 0.07
In studies that have been performed in the past, erythropoietin (EPO) has been shown to be produced by the regenerating liver after partial hepatectomy in rats [5] and erythropoietic foci have been found 24-72 hours after subtotal hepatectomy in rats [6].
Gene_expression (produced) of EPO in liver
13) Confidence 0.77 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2917416 Disease Relevance 0.29 Pain Relevance 0.11
Previous studies suggested that erythropoietin (EPO) was produced in rats by the regenerating liver [6] following partial hepatectomy and erythropoietic foci have been recognized 24-72 hours after subtotal hepatectomy in rats [6].
Gene_expression (produced) of erythropoietin in liver
14) Confidence 0.77 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2917416 Disease Relevance 0.17 Pain Relevance 0.10
In studies that have been performed in the past, erythropoietin (EPO) has been shown to be produced by the regenerating liver after partial hepatectomy in rats [5] and erythropoietic foci have been found 24-72 hours after subtotal hepatectomy in rats [6].
Gene_expression (produced) of erythropoietin in liver
15) Confidence 0.77 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2917416 Disease Relevance 0.30 Pain Relevance 0.11
Previous studies suggested that erythropoietin (EPO) was produced in rats by the regenerating liver [6] following partial hepatectomy and erythropoietic foci have been recognized 24-72 hours after subtotal hepatectomy in rats [6].
Gene_expression (produced) of EPO in liver
16) Confidence 0.77 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2917416 Disease Relevance 0.12 Pain Relevance 0.08
Erythropoietin production by a hepatic adenoma in a patient with severe erythrocytosis.
Gene_expression (production) of Erythropoietin associated with adenoma and erythrocytosis
17) Confidence 0.77 Published 2009 Journal Acta Haematol. Section Title Doc Link 19339771 Disease Relevance 0.96 Pain Relevance 0.09
Immunohistochemistry demonstrated erythropoietin expression in the adenomatous cells.
Gene_expression (expression) of erythropoietin
18) Confidence 0.77 Published 2009 Journal Acta Haematol. Section Abstract Doc Link 19339771 Disease Relevance 0.97 Pain Relevance 0.09
Apart from the red cell surface, erythropoietin's receptor (Epo-R) is also expressed in a large variety of normal tissues.
Gene_expression (expressed) of Epo
19) Confidence 0.74 Published 2007 Journal Clin Neurol Neurosurg Section Abstract Doc Link 17624659 Disease Relevance 0.31 Pain Relevance 0.26
Apart from the red cell surface, erythropoietin's receptor (Epo-R) is also expressed in a large variety of normal tissues.
Gene_expression (expressed) of erythropoietin
20) Confidence 0.74 Published 2007 Journal Clin Neurol Neurosurg Section Abstract Doc Link 17624659 Disease Relevance 0.31 Pain Relevance 0.27

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