INT284300

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Context Info
Confidence 0.18
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.91
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr4) plasma membrane (Tlr4) intracellular (Tlr4)
cytoplasm (Tlr4)
Anatomy Link Frequency
macrophages 4
Tlr4 (Mus musculus)
Mir155 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 10 95.20 Very High Very High Very High
Inflammatory response 24 79.68 Quite High
Inflammatory mediators 2 79.28 Quite High
chemokine 6 78.08 Quite High
Inflammation 26 56.24 Quite High
cINOD 2 30.80 Quite Low
antagonist 2 20.12 Low Low
Arthritis 10 12.88 Low Low
rheumatoid arthritis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 20 98.92 Very High Very High Very High
Acute-phase Reaction 4 98.80 Very High Very High Very High
Infection 2 81.40 Quite High
INFLAMMATION 54 79.32 Quite High
Disease 14 55.20 Quite High
Targeted Disruption 4 48.44 Quite Low
Autoimmune Disease 2 20.32 Low Low
Arthritis 10 12.88 Low Low
Rheumatoid Arthritis 4 5.00 Very Low Very Low Very Low
Neutropenia 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we show that c/ebp Beta is a bona fide target of miR-155 and that LPS treatment of murine macrophages strongly induces miR-155 expression, leading to translational repression of c/ebp Beta.
LPS Positive_regulation (induces) of Gene_expression (expression) of miR-155 in macrophages associated with repression
1) Confidence 0.18 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2761263 Disease Relevance 0.50 Pain Relevance 0.24
We report here that LPS treatment induces miR-155 expression in cultured mouse macrophages and in mouse splenocytes in vivo and that silencing of miR-155 leads to derepression of its direct target c/ebp Beta in vitro and in vivo.
LPS Positive_regulation (induces) of Gene_expression (expression) of miR-155 in macrophages
2) Confidence 0.15 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2761263 Disease Relevance 0.41 Pain Relevance 0.23

General Comments

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