INT284302

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Context Info
Confidence 0.00
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.64
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gnas) endosome (Gnas) signal transduction (Gnas)
extracellular region (Gnas) plasma membrane (Gnas) GTPase activity (Gnas)
Anatomy Link Frequency
macrophages 2
Mir155 (Mus musculus)
Gnas (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 48 50.00 Quite Low
Inflammation 52 5.00 Very Low Very Low Very Low
cytokine 20 5.00 Very Low Very Low Very Low
Arthritis 20 5.00 Very Low Very Low Very Low
chemokine 12 5.00 Very Low Very Low Very Low
rheumatoid arthritis 8 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 40 95.40 Very High Very High Very High
INFLAMMATION 108 50.00 Quite Low
Disease 28 5.00 Very Low Very Low Very Low
Arthritis 20 5.00 Very Low Very Low Very Low
Targeted Disruption 8 5.00 Very Low Very Low Very Low
Acute-phase Reaction 8 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 8 5.00 Very Low Very Low Very Low
Neutropenia 8 5.00 Very Low Very Low Very Low
Body Weight 4 5.00 Very Low Very Low Very Low
Arthropathy 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, our data suggest that the levels of individual c/ebp Beta isoforms are regulated by ectopically expressed miR-155.


miR-155 Regulation (regulated) of isoforms
1) Confidence 0.00 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2761263 Disease Relevance 0.32 Pain Relevance 0
Transfection of the LNA-antimiR (5 nM) into the Raw264.7 macrophages prior to LPS stimulation resulted in derepression of the c/ebp Beta isoforms (Figure 3), which thereby provides additional evidence that the levels of individual c/ebp Beta isoforms are regulated by endogenous miR-155 in mouse macrophages during LPS stimulation.
miR-155 Regulation (regulated) of isoforms in macrophages
2) Confidence 0.00 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2761263 Disease Relevance 0.06 Pain Relevance 0
Figure 3.Regulation of c/ebp Beta isoforms by endogenous miR-155 in Raw264.7 cells during LPS stimulation.
miR-155 Regulation (3.Regulation) of isoforms
3) Confidence 0.00 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2761263 Disease Relevance 0.06 Pain Relevance 0
To assess miR-155-mediated regulation of the various c/ebp Beta isoforms, we investigated protein extracts from murine macrophages by Western blot analyses using a C-terminal specific c/ebp Beta antibody that recognizes all three isoforms.
miR-155-mediated Regulation (regulation) of isoforms in macrophages
4) Confidence 0.00 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2761263 Disease Relevance 0.19 Pain Relevance 0

General Comments

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