INT284306

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Context Info
Confidence 0.00
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.19
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr4, Adrb3) plasma membrane (Tlr4, Adrb3) nucleus (Adrb3)
intracellular (Tlr4) signal transducer activity (Adrb3) cytoplasm (Tlr4)
Anatomy Link Frequency
macrophages 2
monocytes 2
Tlr4 (Mus musculus)
Adrb3 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 20 97.00 Very High Very High Very High
Inflammatory response 48 90.40 High High
chemokine 12 65.96 Quite High
Inflammation 52 36.72 Quite Low
antagonist 4 30.84 Quite Low
cINOD 4 11.28 Low Low
Arthritis 20 5.00 Very Low Very Low Very Low
rheumatoid arthritis 8 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acute-phase Reaction 8 93.84 High High
INFLAMMATION 108 90.04 High High
Targeted Disruption 8 59.16 Quite High
Repression 40 46.32 Quite Low
Disease 28 35.68 Quite Low
Arthritis 20 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 8 5.00 Very Low Very Low Very Low
Neutropenia 8 5.00 Very Low Very Low Very Low
Body Weight 4 5.00 Very Low Very Low Very Low
Arthropathy 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previous studies have shown that the transcription factor CCAAT/enhancer binding protein Beta (c/ebp Beta) is induced in monocytes and macrophages by LPS (14) and that c/ebp Beta is involved in the regulation of proinflammatory cytokines as well as other genes associated with macrophage activation and the acute phase response (15,16).
LPS Positive_regulation (induced) of Beta in monocytes associated with acute-phase reaction and cytokine
1) Confidence 0.00 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2761263 Disease Relevance 0.30 Pain Relevance 0.19
Previous studies have shown that the transcription factor CCAAT/enhancer binding protein Beta (c/ebp Beta) is induced in monocytes and macrophages by LPS (14) and that c/ebp Beta is involved in the regulation of proinflammatory cytokines as well as other genes associated with macrophage activation and the acute phase response (15,16).
LPS Positive_regulation (induced) of Beta in monocytes associated with acute-phase reaction and cytokine
2) Confidence 0.00 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2761263 Disease Relevance 0.30 Pain Relevance 0.19
Previous studies have shown that the transcription factor CCAAT/enhancer binding protein Beta (c/ebp Beta) is induced in monocytes and macrophages by LPS (14) and that c/ebp Beta is involved in the regulation of proinflammatory cytokines as well as other genes associated with macrophage activation and the acute phase response (15,16).
LPS Positive_regulation (induced) of Beta in macrophages associated with acute-phase reaction and cytokine
3) Confidence 0.00 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2761263 Disease Relevance 0.30 Pain Relevance 0.19
Previous studies have shown that the transcription factor CCAAT/enhancer binding protein Beta (c/ebp Beta) is induced in monocytes and macrophages by LPS (14) and that c/ebp Beta is involved in the regulation of proinflammatory cytokines as well as other genes associated with macrophage activation and the acute phase response (15,16).
LPS Positive_regulation (induced) of Beta in macrophages associated with acute-phase reaction and cytokine
4) Confidence 0.00 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2761263 Disease Relevance 0.30 Pain Relevance 0.19

General Comments

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