INT284313

Context Info Confidence 0.07 First Reported 2009 Last Reported 2009 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.32 Pain Relevance 0

cytoplasm (IRS1, SART3) nucleus (IRS1, SART3) intracellular (SART3) signal transducer activity (IRS1) cytosol (IRS1) signal transduction (IRS1)

IRS1 (Homo sapiens) SART3 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 2 33.64 tolerance 4 5.00 lidocaine 2 5.00

Disease Link Frequency Relevance Heat Insulin Resistance 28 96.12 Hyperinsulinism 8 75.04 INFLAMMATION 2 33.64 Overnutrition 28 19.76 Diabetes Mellitus 10 5.00 Weight Gain 6 5.00 Impaired Glucose Tolerance 4 5.00 Obesity 4 5.00 Cardiovascular Disease 2 5.00 Rheumatoid Arthritis 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Therefore, we examined association of p110 with IRS-1 in response to insulin in patients after 5 days of overfeeding either HC or HF compared to 5 days of eucaloric feeding.

IRS-1 Spec (examined) Binding (association) of p110

1) Confidence 0.07 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2761378 Disease Relevance 0 Pain Relevance 0

and decreased association of p110 with IRS-1 and decreased insulin-stimulated PI 3-kinase activity.

IRS-1 Binding (association) of p110

2) Confidence 0.07 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2761378 Disease Relevance 0.32 Pain Relevance 0

General Comments

This test has worked.