INT284325

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Context Info
Confidence 0.13
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.08
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (DAG1) extracellular space (DAG1) extracellular region (DAG1)
plasma membrane (DAG1) cytoskeleton (DAG1) nucleus (DAG1)
Anatomy Link Frequency
fat 2
HL-60 2
neutrophil 2
DAG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 10 98.96 Very High Very High Very High
cytokine 15 78.12 Quite High
Bioavailability 1 59.36 Quite High
Inflammation 30 50.00 Quite Low
imagery 22 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
bradykinin 3 5.00 Very Low Very Low Very Low
Cholecystokinin 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperglycemia 38 99.98 Very High Very High Very High
Apoptosis 89 88.04 High High
Insulin Resistance 41 87.68 High High
Fungal Infection 38 79.92 Quite High
Diabetic Retinopathy 3 78.56 Quite High
Stress 31 70.96 Quite High
Hypoxia 3 62.00 Quite High
Sprains And Strains 12 59.52 Quite High
Cryptococcus Infection 10 57.44 Quite High
INFLAMMATION 30 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also provide evidence supporting a mechanism by which SMS regulates neutrophil killing against C. neoformans through the production of DAG and the consequent activation of protein kinase D (PKD).


Positive_regulation (activation) of Gene_expression (production) of DAG in neutrophil
1) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3011003 Disease Relevance 0.30 Pain Relevance 0.04
Total DAG levels increased in differentiated versus undifferentiated HL-60 cells (Figure 6A).
Positive_regulation (increased) of Gene_expression (levels) of DAG in HL-60
2) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3011003 Disease Relevance 0.08 Pain Relevance 0
Ceremide and diacylglycerol (DAG) have been linked to deleterious effects on insulin signaling in muscle and DAG levels can increase following intake of a diet high in saturated fat [60,61].
Positive_regulation (increase) of Gene_expression (muscle) of DAG in fat
3) Confidence 0.07 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2761378 Disease Relevance 0.14 Pain Relevance 0
Hyperglycemia increases the levels of DAG, which in turn activates PKC.
Positive_regulation (increases) of Gene_expression (levels) of DAG associated with hyperglycemia and kinase c
4) Confidence 0.06 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 0.56 Pain Relevance 0.32

General Comments

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