INT284334

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Context Info
Confidence 0.49
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 12
Disease Relevance 5.81
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IRS1) signal transduction (IRS1) plasma membrane (IRS1)
nucleus (IRS1) cytoplasm (IRS1) signal transducer activity (IRS1)
Anatomy Link Frequency
colon 1
skeletal muscle 1
adipocyte 1
IRS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 57 94.56 High High
cytokine 48 89.12 High High
tolerance 16 87.68 High High
rheumatoid arthritis 1 76.72 Quite High
spinal inflammation 2 72.32 Quite High
withdrawal 4 71.96 Quite High
Etanercept 1 32.56 Quite Low
Somatostatin 12 11.64 Low Low
Kinase C 10 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metabolic Syndrome 223 99.84 Very High Very High Very High
Insulin Resistance 119 98.84 Very High Very High Very High
Colon Cancer 3 98.12 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

12 97.04 Very High Very High Very High
Hyperglycemia 38 96.36 Very High Very High Very High
Overnutrition 56 94.72 High High
INFLAMMATION 53 94.56 High High
Obesity 24 94.24 High High
Increased Venous Pressure Under Development 31 92.80 High High
Disease 22 88.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Anti-IRS-1 was obtained from Upstate (Charlottesville, VA, USA) and anti-Insulin Receptor alpha was from Santa Cruz Biotechnology (Heidelberg, Germany)
Gene_expression (obtained) of IRS-1
1) Confidence 0.49 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940873 Disease Relevance 0.35 Pain Relevance 0.03
Therefore, IS of insulin seems to be impaired at least at the IRS-1 level in MetS.
Gene_expression (level) of IRS-1 associated with metabolic syndrome
2) Confidence 0.49 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940873 Disease Relevance 0.65 Pain Relevance 0.04
Antibodies to IRS-1, and p85?
Gene_expression (Antibodies) of IRS-1
3) Confidence 0.45 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2761378 Disease Relevance 0.40 Pain Relevance 0.09
Surprisingly, in our study p-serine-636/639-IRS-1 was significantly less in patients with MetS while there was a slight increased total IRS-1, although this was not statistical significant.
Gene_expression (less) of 639-IRS-1 associated with metabolic syndrome
4) Confidence 0.43 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940873 Disease Relevance 0.68 Pain Relevance 0.12
Immunoprecipitated IRS-1 was also immunoblotted with p110 antibodies to determine the total amount of IRS-1-associated p110 expression.
Gene_expression (expression) of IRS-1-associated
5) Confidence 0.40 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2761378 Disease Relevance 0 Pain Relevance 0
Five days of HC overfeeding resulted in significant increases in tyrosine phosphorylation of IRS-1 (Figure 1A), with no change in total IRS-1 protein expression compared to EC feeding (Figure 2).
Gene_expression (expression) of IRS-1
6) Confidence 0.40 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2761378 Disease Relevance 0.06 Pain Relevance 0.03
In contrast, HF overfeeding increased skeletal muscle serine phosophorylation of IRS-1 (p < 0.001) and increased total expression of p85?
Gene_expression (expression) of IRS-1 in skeletal muscle
7) Confidence 0.40 Published 2009 Journal Nutr Metab (Lond) Section Abstract Doc Link PMC2761378 Disease Relevance 0.24 Pain Relevance 0
Figure 4 shows the insulin receptor expression, Figure 5 total IRS-1 and Figure 6 inactive form of IRS-1 in humans (serine-636/639-phosphorylated-IRS-1).
Gene_expression (expression) of IRS-1
8) Confidence 0.38 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940873 Disease Relevance 0.40 Pain Relevance 0
The potential target genes of miR-145 encode oncogenic proteins, such as myc, kras, fos, yes, fli, cyclin D2, and MAPK transduction proteins [31]. miR-145 targets the insulin receptor substrate-1 (IRS-1) and miR-151-3p targets the insulin receptor substrate-4 (IRS-4), which regulated cell communication, receptor and membrane activities.
Gene_expression (targets) of IRS-1
9) Confidence 0.18 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3017030 Disease Relevance 0.35 Pain Relevance 0
Furthermore, Shi et al. [32] demonstrated experimentally that miR145 targeted IRS-1 and had a profound biological effect on human colon cancer cells.
Gene_expression (targeted) of IRS-1 in colon associated with colon cancer
10) Confidence 0.18 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3017030 Disease Relevance 0.44 Pain Relevance 0
The potential target genes of miR-145 encode oncogenic proteins, such as myc, kras, fos, yes, fli, cyclin D2, and MAPK transduction proteins [31]. miR-145 targets the insulin receptor substrate-1 (IRS-1) and miR-151-3p targets the insulin receptor substrate-4 (IRS-4), which regulated cell communication, receptor and membrane activities.
Gene_expression (targets) of insulin receptor substrate-1
11) Confidence 0.18 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3017030 Disease Relevance 0.35 Pain Relevance 0
A low adipocyte IRS-1 expression may thereby be a marker for insulin resistance [19, 56, 57].

5.4.

Gene_expression (expression) of IRS-1 in adipocyte associated with insulin resistance
12) Confidence 0.16 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 1.78 Pain Relevance 0.28

General Comments

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