INT284337

Context Info Confidence 0.42 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.29 Pain Relevance 0.11

small molecule metabolic process (LCT) plasma membrane (LCT) carbohydrate metabolic process (LCT)

LCT (Homo sapiens)

Pain Link Frequency Relevance Heat abdominal pain 1 73.56 nud 1 72.44

Disease Link Frequency Relevance Heat Diarrhoea 1 74.08 Abdominal Pain 1 73.56 Flatulence 1 72.92 Dyspepsia 1 72.44 Lactose Intolerance 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The DNA region of the LCT -13910C>T lactase persistence-non persistence variant functioned in vitro as a cis regulatory element capable of enhancing differential transcriptional activation of the lactase promoter that is consistent with a causative role in the mechanism of lactase persistence/non-persistence phenotypes in humans [6].

Positive_regulation (enhancing) of Positive_regulation (activation) of lactase

1) Confidence 0.42 Published 2009 Journal Nutr J Section Body Doc Link PMC2761420 Disease Relevance 0.29 Pain Relevance 0.11

General Comments

This test has worked.