INT284357

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Context Info
Confidence 0.38
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.78
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mvk) mRNA binding (Mvk) peroxisome (Mvk)
kinase activity (Mvk) cytoplasm (Mvk)
Anatomy Link Frequency
bar 2
Mvk (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 12 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
abdominal pain 3 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Osteoarthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Mevalonate Kinase Deficiency 174 99.84 Very High Very High Very High
Osteoporosis 4 65.36 Quite High
Osteogenic Sarcomas 3 59.52 Quite High
Fever 15 5.00 Very Low Very Low Very Low
INFLAMMATION 12 5.00 Very Low Very Low Very Low
Syndrome 9 5.00 Very Low Very Low Very Low
Cancer 5 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
Hypergammaglobulinemia 3 5.00 Very Low Very Low Very Low
Dementia 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the MK enzyme activity can barely be detected in MKD cells, we previously showed that protein isoprenylation is usually rather normal when these cells are cultured under normal conditions (Houten et al 2003b).
Gene_expression (detected) of MK enzyme associated with mevalonate kinase deficiency
1) Confidence 0.38 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 0.41 Pain Relevance 0
Control and mevalonate kinase deficient (MKD) cells were incubated with 0 (white bar; set as 100%), 0.02 (grey bar), or 0.2 ?
Gene_expression (Control) of mevalonate kinase in bar associated with mevalonate kinase deficiency
2) Confidence 0.37 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 0.76 Pain Relevance 0
Control and mevalonate kinase deficient (MKD) cells were incubated with 0 (white bar), 0.02 (grey bar), or 0.2 ?
Gene_expression (Control) of mevalonate kinase in bar associated with mevalonate kinase deficiency
3) Confidence 0.37 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 0.49 Pain Relevance 0
Thus all media were supplemented with 100ng/ml IGF-I (Peprotech Inc., Rocky Hill, NJ, USA) to ensure activation of the mevalonate pathway and expression of VEGF.
Gene_expression (expression) of of the mevalonate pathway
4) Confidence 0.06 Published 2009 Journal The Open Orthopaedics Journal Section Body Doc Link PMC2761671 Disease Relevance 0.12 Pain Relevance 0

General Comments

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