INT284438

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Context Info
Confidence 0.49
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.98
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il11) extracellular region (Il11) cytoplasm (Il11)
Anatomy Link Frequency
bowel 2
intestine 2
Il11 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 6 99.36 Very High Very High Very High
Inflammation 111 97.36 Very High Very High Very High
cytokine 53 26.04 Quite Low
agonist 2 23.16 Low Low
Inflammatory response 14 5.00 Very Low Very Low Very Low
metalloproteinase 8 5.00 Very Low Very Low Very Low
Inflammatory mediators 7 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Bioavailability 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 1 98.48 Very High Very High Very High
Inflammatory Bowel Disease 12 97.74 Very High Very High Very High
INFLAMMATION 123 97.12 Very High Very High Very High
Disease 16 96.68 Very High Very High Very High
Cancer 301 93.84 High High
Stress 25 93.40 High High
Wound Healing 4 91.28 High High
Colitis 18 89.80 High High
Atherosclerosis 53 89.40 High High
Apoptosis 24 87.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sections were washed, re-blocked in NDS and incubated overnight with a goat anti-IL-11R?
Positive_regulation (incubated) of Gene_expression (washed) of IL-11
1) Confidence 0.49 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0
Although the two pathways share transcriptional responsiveness of proliferative target genes, such as c-myc and cyclinD1, IL11 administration and excessive Stat3 activation also facilitates survival of epithelial cells with the capacity to repopulate the intestine after radiation damage [92] (Phesse T, Buchert M, Ernst M: Epistatic interaction between aberrant Wnt and Stat3 signaling during intestinal tumorigenesis, submitted).
Positive_regulation (activation) of Gene_expression (administration) of IL11 in intestine
2) Confidence 0.29 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 0.46 Pain Relevance 0
In humans STAT3 represents one of the disease loci for Crohn's and inflammatory bowel disease (IBD) [99], and most likely relates to the capacity of Stat3 to promote intestinal barrier function and integrity in response to IL6, IL11 and IL22 exposure.
Positive_regulation (response) of Gene_expression (exposure) of IL11 in bowel associated with inflammatory bowel disease, inflammation and disease
3) Confidence 0.29 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 1.11 Pain Relevance 0.12
Some representative examples include proinflammatory genes such as Interleukin 8 (IL-8) and chemokine (C-X-C motif) ligand 1 (CXCL1) production, immune response genes such as Interleukin 11 (IL-11) and UPR genes such as activating transcription factor 4 (ATF 4), heat shock 70 kDa protein 8 (HSPA8) and X-box binding protein 1 (XBP1).
Positive_regulation (activating) of Gene_expression (production) of Interleukin 11 associated with chemokine and shock
4) Confidence 0.07 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2761850 Disease Relevance 0.42 Pain Relevance 0.05

General Comments

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