INT284453

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Context Info
Confidence 0.32
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.23
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (Eif2ak2) nucleus (Eif2ak2) intracellular (Eif2ak2)
translation (Eif2ak2) kinase activity (Eif2ak2)
Eif2ak2 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 84 98.60 Very High Very High Very High
addiction 2 95.80 Very High Very High Very High
Inflammation 40 94.88 High High
palliative 2 62.36 Quite High
cytokine 30 52.36 Quite High
chemokine 19 5.00 Very Low Very Low Very Low
Inflammatory mediators 10 5.00 Very Low Very Low Very Low
Inflammatory response 7 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
cva 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 55 94.88 High High
Pressure And Volume Under Development 4 80.64 Quite High
Stress 2 78.96 Quite High
Sepsis 21 75.20 Quite High
Volume Depletion And Dehydration 1 72.36 Quite High
Lung Injury 6 70.56 Quite High
Adult Respiratory Distress Syndrome 23 52.72 Quite High
Pneumonia 9 51.20 Quite High
Targeted Disruption 6 25.92 Quite Low
Injury 7 22.72 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the canonical model for PKR activation requires its interaction with exogenous RNAs not known to be produced downstream of TLR ligation, multiple studies have reported roles for PKR in the cellular response to LPS.
Positive_regulation (requires) of Positive_regulation (activation) of PKR
1) Confidence 0.32 Published 2010 Journal mBio Section Body Doc Link PMC2962435 Disease Relevance 0.20 Pain Relevance 0.27
Delineation of the precise TLR-inducible signaling complexes leading to PKR activation will be a compelling avenue for investigation and should expand our understanding of TLR signaling.
Positive_regulation (leading) of Positive_regulation (activation) of PKR
2) Confidence 0.22 Published 2010 Journal mBio Section Body Doc Link PMC2962435 Disease Relevance 0.14 Pain Relevance 0.16
In addition, DAI-1, previously named DLM-1 or Z-DNA binding protein 1, has been identified as a cytoplasmic receptor that senses and is activated by DNA, leading to type I IFN gene induction [31].
Positive_regulation (leading) of Positive_regulation (induction) of type I IFN gene
3) Confidence 0.04 Published 2009 Journal Respir Res Section Body Doc Link PMC2761862 Disease Relevance 0.90 Pain Relevance 0.28

General Comments

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