INT284454

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Context Info
Confidence 0.26
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 2.07
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tirap) intracellular (Tirap) cytoplasm (Tirap)
Anatomy Link Frequency
macrophages 1
B cells 1
dendritic cells 1
Tirap (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 104 85.84 High High
Inflammation 88 77.04 Quite High
Inflammatory mediators 24 34.32 Quite Low
chemokine 55 6.56 Low Low
Inflammatory response 25 5.00 Very Low Very Low Very Low
metalloproteinase 10 5.00 Very Low Very Low Very Low
cva 9 5.00 Very Low Very Low Very Low
fibrosis 6 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 43 84.32 Quite High
Adult Respiratory Distress Syndrome 69 77.40 Quite High
INFLAMMATION 131 77.04 Quite High
Pneumonia 27 65.56 Quite High
Shock 7 51.20 Quite High
Apoptosis 19 49.40 Quite Low
Leukostasis 3 46.80 Quite Low
Myocardial Infarction 54 45.04 Quite Low
Cancer 4 39.76 Quite Low
Necrosis 13 39.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ligand stimulation recruits adaptor molecules TIRAP (TIR domain-containing adaptor protein) or TRAM (TRIF-related adaptor molecule).
TIRAP Binding (recruits) of
1) Confidence 0.26 Published 2010 Journal Heart Fail Rev Section Body Doc Link PMC3003782 Disease Relevance 0 Pain Relevance 0
MyD88-dependent signalling via TLR2 and TLR4 requires the presence of TIRAP and will end after several steps in activation of NF?
TIRAP Binding (presence) of
2) Confidence 0.26 Published 2010 Journal Heart Fail Rev Section Body Doc Link PMC3003782 Disease Relevance 0.05 Pain Relevance 0.03
Upon recognition of CpG-rich sequences in the endosome, TLR9, expressed by B cells, macrophages, and dendritic cells (DCs), initiates a conserved TLR family signaling cascade that begins with the recruitment of the adaptor protein MyD88, resulting in NF-?
adaptor protein MyD88 Binding (recruitment) of in dendritic cells
3) Confidence 0.02 Published 2009 Journal Respir Res Section Body Doc Link PMC2761862 Disease Relevance 0.67 Pain Relevance 0.15
Upon recognition of CpG-rich sequences in the endosome, TLR9, expressed by B cells, macrophages, and dendritic cells (DCs), initiates a conserved TLR family signaling cascade that begins with the recruitment of the adaptor protein MyD88, resulting in NF-?
adaptor protein MyD88 Binding (recruitment) of in B cells
4) Confidence 0.01 Published 2009 Journal Respir Res Section Body Doc Link PMC2761862 Disease Relevance 0.67 Pain Relevance 0.15
Upon recognition of CpG-rich sequences in the endosome, TLR9, expressed by B cells, macrophages, and dendritic cells (DCs), initiates a conserved TLR family signaling cascade that begins with the recruitment of the adaptor protein MyD88, resulting in NF-?
adaptor protein MyD88 Binding (recruitment) of in macrophages
5) Confidence 0.01 Published 2009 Journal Respir Res Section Body Doc Link PMC2761862 Disease Relevance 0.67 Pain Relevance 0.15

General Comments

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