INT2845

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Context Info
Confidence 0.78
First Reported 1979
Last Reported 2006
Negated 0
Speculated 1
Reported most in Abstract
Documents 6
Total Number 11
Disease Relevance 3.97
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (ID1) cytoplasm (ID1)
Anatomy Link Frequency
hepatocytes 1
skin 1
A2780 1
kidney 1
ID1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 7 97.28 Very High Very High Very High
Analgesic 2 90.12 High High
cINOD 4 75.80 Quite High
Inflammation 10 23.28 Low Low
psoriasis 15 5.00 Very Low Very Low Very Low
withdrawal 10 5.00 Very Low Very Low Very Low
metalloproteinase 10 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 135 99.92 Very High Very High Very High
Stomach Cancer 24 99.84 Very High Very High Very High
Psoriasis 25 99.12 Very High Very High Very High
Aging 5 98.88 Very High Very High Very High
Ovarian Cancer 5 97.28 Very High Very High Very High
Uremia 3 97.20 Very High Very High Very High
Renal Disease 2 95.92 Very High Very High Very High
Colorectal Cancer 5 72.68 Quite High
Death 4 71.20 Quite High
Leukemia 5 43.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Id-1 was frequently and strongly expressed in gastric cancer tissues compared with that in adjacent nonmetaplastic mucosa.
Gene_expression (expressed) of Id-1 associated with stomach cancer
1) Confidence 0.78 Published 2006 Journal Int. J. Cancer Section Abstract Doc Link 16184548 Disease Relevance 0.75 Pain Relevance 0.06
Id-1 expression level was decreased dose-dependently by sulindac sulfide.
Gene_expression (expression) of Id-1
2) Confidence 0.78 Published 2006 Journal Int. J. Cancer Section Abstract Doc Link 16184548 Disease Relevance 0.53 Pain Relevance 0.08
We also examined Id-1 expression in human gastric cancer tissues and compared it with clinicopathologic parameters to study its biologic role in the cancers.
Spec (examined) Gene_expression (expression) of Id-1 associated with cancer and stomach cancer
3) Confidence 0.78 Published 2006 Journal Int. J. Cancer Section Abstract Doc Link 16184548 Disease Relevance 0.70 Pain Relevance 0.07
In addition, the expression pattern of Id-1 was inversely related to that of nm23.
Gene_expression (expression) of Id-1
4) Confidence 0.78 Published 2006 Journal Int. J. Cancer Section Abstract Doc Link 16184548 Disease Relevance 0.66 Pain Relevance 0.07
ID1 expression was also increased by dimethylnitrosamine, acetylaminofluorene and acetaminophen in both primary hepatocytes and HepG2.
Gene_expression (expression) of ID1 in hepatocytes associated with paracetamol
5) Confidence 0.77 Published 2004 Journal Mutat. Res. Section Abstract Doc Link 15120964 Disease Relevance 0 Pain Relevance 0.16
This correlates well with our results on repressed ID-1 expression, since both BMP-2 and -4 up-regulate ID-1 [64,65].
Gene_expression (expression) of ID-1
6) Confidence 0.55 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0.13 Pain Relevance 0
The ID-1 expression is regulated by a protein complex containing the immediate-early response gene EGR1 [19].
Gene_expression (expression) of ID-1
7) Confidence 0.55 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0.26 Pain Relevance 0
Overexpression of ID-1 was also reported in psoriatic involved skin [16].
Gene_expression (Overexpression) of ID-1 in skin associated with psoriasis
8) Confidence 0.55 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0.25 Pain Relevance 0
Analysis of ID-1 expression levels by real-time quantitative PCR confirmed the suppression of the transcript in both cell types (Table 3).
Gene_expression (expression) of ID-1
9) Confidence 0.55 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0 Pain Relevance 0
The cell cycle blockade and differentiation caused by such a drug, trichostatin A, caused decreased levels of ID-1 consistent with cell cycle senescence and differentiation of A2780 ovarian cancer cells [17].
Gene_expression (levels) of ID-1 in A2780 associated with aging and ovarian cancer
10) Confidence 0.42 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0.29 Pain Relevance 0
Determinations of immuno-detectable Erythropoietin (idEP), haematocrit (Hct), reticulocyte counts (RC) and serum iron (SI) in uraemic patients with different kidney diseases (KD) and various lengths of chronic haemodialysis treatment (HDT) revealed firstly that all patients had normal idEP, except for analgesic nephropathies who had significantly higher idEP levels; secondly that over six years of haemodialysis idEP increased by about 40% but without concomitant Hct improvement and thirdly that there were no clear interdependencies between Hct, SI, RC and idEP in uraemic patients.
Gene_expression (immuno-detectable) of idEP in kidney associated with analgesic, renal disease and uremia
11) Confidence 0.01 Published 1979 Journal Proc Eur Dial Transplant Assoc Section Abstract Doc Link 548991 Disease Relevance 0.42 Pain Relevance 0.09

General Comments

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