INT284514

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Context Info
Confidence 0.20
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.19
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (PF4) extracellular region (PF4)
Anatomy Link Frequency
platelet 2
PF4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 6 84.12 Quite High
cva 24 63.36 Quite High
aspirin 3 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Heparin-induced Thrombocytopenia 6 98.06 Very High Very High Very High
Pain 6 84.12 Quite High
Hemorrhage 13 83.08 Quite High
Peripheral Arterial Disease 12 81.32 Quite High
Hematoma 1 78.12 Quite High
Cv General 3 Under Development 10 63.36 Quite High
Disease 6 51.20 Quite High
Pressure Volume 2 Under Development 1 41.28 Quite Low
Hepatic Insufficiency 1 39.20 Quite Low
Pressure And Volume Under Development 1 37.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Heparin-induced thrombocytopenia (HIT) is another well known complication of heparin, its incidence being approximately 0.8%, with LMWH, about 3-fold lower than with UFH.67,68 HIT is caused by heparin-dependent antibodies (usually immunoglobulin G) binding a confirmationally modified epitope on platelet factor 4 (PF4), its modified structure being subsequently recognized as a foreign protein by the immunocompetent cells of the patients.
Regulation (modified) of Regulation (epitope) of PF4 in platelet associated with heparin-induced thrombocytopenia
1) Confidence 0.20 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2762431 Disease Relevance 1.19 Pain Relevance 0.12

General Comments

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