INT284546

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Context Info
Confidence 0.29
First Reported 2009
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 6.73
Pain Relevance 1.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cxcr7) plasma membrane (Cxcr7) signal transducer activity (Cxcr7)
Anatomy Link Frequency
Poly 1
Cxcr7 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 67 98.12 Very High Very High Very High
cytokine 24 91.24 High High
agonist 44 90.40 High High
Inflammation 64 85.72 High High
isoflurane 12 5.00 Very Low Very Low Very Low
imagery 12 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Carcinoma 75 98.16 Very High Very High Very High
Disease 102 97.92 Very High Very High Very High
Infection 172 97.76 Very High Very High Very High
Colon Cancer 75 94.96 High High
Death 25 94.96 High High
Influenza Virus Infection 32 94.32 High High
Metastasis 75 93.96 High High
Adhesions 105 93.48 High High
Severe Acute Respiratory Syndrome 152 92.64 High High
Respiratory Syncytial Virus 16 92.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In agreement with CXCR4, upregulation of CXCR7 enhances the metastatic potential of several carcinomas [26].
Positive_regulation (upregulation) of CXCR7 associated with carcinoma
1) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 1.37 Pain Relevance 0.18
It is also of interest to examine if transient and constitutive CXCL12 stimulation of either CXCR4 or CXCR7 elicits distinct cellular outcomes.
Spec (examine) Positive_regulation (stimulation) of CXCR7
2) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 0.89 Pain Relevance 0.17
The impact of sustained CXCR4 and CXCR7 activation on the desensitization and recycling of those receptors has yet to be explored, but may provide novel avenues with which we can specifically activate or de-activate chemokine receptors in human disease.
Positive_regulation (activation) of CXCR7 associated with chemokine and disease
3) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 0.67 Pain Relevance 0.13
This transfer was successful because inhibitory AMs cannot reverse prior rDC activation (Fig. 7 A).
Neg (cannot) Positive_regulation (activation) of rDC
4) Confidence 0.08 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2762542 Disease Relevance 0.70 Pain Relevance 0.03
AM depletion enhanced rDC activation, migration and recruitment
Positive_regulation (activation) of rDC
5) Confidence 0.06 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2762542 Disease Relevance 1.27 Pain Relevance 0.38
Overall rDC activation is a prerequisite for initiation and maintenance of the immune response.
Positive_regulation (activation) of rDC
6) Confidence 0.06 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2762542 Disease Relevance 1.09 Pain Relevance 0.07
Poly I:C, which activated AMs and rDC in vivo (Fig. 5 C and S7) and in vitro (Fig. 6 A), protected animals from lethal MA15 infection.
Positive_regulation (activated) of rDC in Poly associated with infection
7) Confidence 0.06 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2762542 Disease Relevance 0.74 Pain Relevance 0.17

General Comments

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