INT284548

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Context Info
Confidence 0.21
First Reported 2009
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.15
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cxcr7) plasma membrane (Cxcr7) signal transducer activity (Cxcr7)
Anatomy Link Frequency
T cell 1
Cxcr7 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 32 100.00 Very High Very High Very High
Inflammation 34 58.48 Quite High
agonist 22 55.20 Quite High
Hippocampus 35 49.72 Quite Low
cytokine 16 27.20 Quite Low
isoflurane 8 5.00 Very Low Very Low Very Low
Central nervous system 7 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 25 97.56 Very High Very High Very High
Infection 86 97.24 Very High Very High Very High
Metastasis 25 96.56 Very High Very High Very High
Carcinoma 25 92.08 High High
Adhesions 35 91.68 High High
Coronavirus Infection 56 82.48 Quite High
Severe Acute Respiratory Syndrome 76 82.32 Quite High
Apoptosis 47 74.24 Quite High
Disease 54 70.16 Quite High
Severe Combined Immunodeficiency 9 59.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To further investigate CXCL12-mediated guidance mechanisms, we next examined expression of CXCR4 and CXCR7, the two receptors that bind CXCL12 [39].
CXCR7 Spec (examined) Binding (bind) of
1) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013129 Disease Relevance 0 Pain Relevance 0.09
Recently CXCL12 has been shown to bind the chemokine receptor CXCR7 [26].
CXCR7 Binding (bind) of associated with chemokine
2) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 1.33 Pain Relevance 0.18
All of these three experimental interventions resulted in enhanced rDC migration to the DLNs, enhanced MA15-specific T cell responses at the site of infection, the lungs, and improved outcomes.
rDC Binding (migration) of in T cell associated with infection
3) Confidence 0.05 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2762542 Disease Relevance 0.76 Pain Relevance 0.03
In all mice, rDC migration to the DLNs peaked at 18 h p.i., but migration was accelerated by treatment with clodronate.
rDC Binding (migration) of
4) Confidence 0.04 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2762542 Disease Relevance 0.06 Pain Relevance 0.03

General Comments

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