INT28457

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Context Info
Confidence 0.50
First Reported 1989
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 26
Total Number 28
Disease Relevance 3.64
Pain Relevance 7.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Slc6a3) plasma membrane (Slc6a3) transmembrane transport (Slc6a3)
Anatomy Link Frequency
livers 3
nucleus accumbens 2
tail 1
striatum 1
brain 1
Slc6a3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 709 100.00 Very High Very High Very High
dopamine receptor 10 100.00 Very High Very High Very High
Nicotine 10 99.56 Very High Very High Very High
imagery 14 99.50 Very High Very High Very High
Morphine 23 99.40 Very High Very High Very High
Nucleus accumbens 22 99.36 Very High Very High Very High
Kinase C 120 97.46 Very High Very High Very High
Substantia nigra 12 94.64 High High
halothane 6 91.88 High High
monoamine 12 88.76 High High
Disease Link Frequency Relevance Heat
Tourette's Syndrome 17 98.88 Very High Very High Very High
Pheochromocytoma 21 98.40 Very High Very High Very High
Breast Cancer 20 96.12 Very High Very High Very High
Sprains And Strains 69 94.96 High High
Body Weight 20 94.32 High High
Hypertrophy 4 94.00 High High
Targeted Disruption 64 93.84 High High
Attention Deficit Hyperactivity Disorder 313 91.52 High High
Depression 75 78.48 Quite High
Stress 36 76.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Functional assays showed that the increased surface DAT led to a corresponding increase in DA uptake but had no effect on DAT affinity for DA.
Positive_regulation (increased) of DAT associated with dopamine
1) Confidence 0.50 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.16
We hypothesize that [DA]e is maintained at a normal level during the increased firing by equally increased activity of the DA transporter.
Positive_regulation (increased) of DA transporter associated with dopamine
2) Confidence 0.47 Published 1994 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 7824039 Disease Relevance 0 Pain Relevance 1.11
Tissues were assayed for D1, D2 and D3 dopamine receptor mRNAs (D1R, D2R and D3R), as well as for mRNAs for tyrosine hydroxylase (TH) and the dopamine transporter (DAT).
Positive_regulation (assayed) of DAT associated with dopamine and dopamine receptor
3) Confidence 0.44 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12654507 Disease Relevance 0 Pain Relevance 0.79
Tissues were assayed for D1, D2 and D3 dopamine receptor mRNAs (D1R, D2R and D3R), as well as for mRNAs for tyrosine hydroxylase (TH) and the dopamine transporter (DAT).
Positive_regulation (assayed) of dopamine transporter associated with dopamine and dopamine receptor
4) Confidence 0.44 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12654507 Disease Relevance 0 Pain Relevance 0.79
An important regulatory mechanism of synaptic dopamine (DA) levels is activation of the dopamine transporter (DAT), which is a target for many drugs of abuse, including amphetamine (AMPH). sigma receptors are located in dopaminergic brain areas critical to reinforcement.
Positive_regulation (activation) of DAT in brain associated with dopamine
5) Confidence 0.44 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10087015 Disease Relevance 0.29 Pain Relevance 0.37
While these results demonstrate the presence of the DAT: CPE protein complex in rat striatal tissue, it does not clarify whether the DAT: CPE protein complex is formed through a direct interaction or is mediated indirectly by an accessory binding protein.
Spec (whether) Positive_regulation (mediated) of DAT
6) Confidence 0.41 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.03
CPE stablized DAT via reducing the phosphorylation state of DAT
Positive_regulation (stablized) of DAT
7) Confidence 0.41 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.08
We have shown that this interaction leads to cell surface stabilization of DAT via reduced degradation, possibly through a reduction in DAT phosphorylation.
Spec (possibly) Positive_regulation (stabilization) of DAT
8) Confidence 0.38 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.18
Taken together, data from our present study and previous reports indicate that protein-protein interactions appear to be important for DAT function.
Positive_regulation (important) of DAT
9) Confidence 0.38 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0.12 Pain Relevance 0.21
Mammalian cell lines coexpressing CPE and DAT exhibited increased DAT-mediated dopamine uptake activity compared to cells expressing DAT alone.
Positive_regulation (increased) of DAT-mediated associated with dopamine
10) Confidence 0.38 Published 2009 Journal Mol Brain Section Abstract Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.17
In contrast, ICS 205-930 (up to 30 micrograms/kg s.c.) failed to affect the amphetamine-induced stimulation of DA release in the nucleus accumbens.
Positive_regulation (stimulation) of DA in nucleus accumbens associated with nucleus accumbens and dopamine
11) Confidence 0.37 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2767122 Disease Relevance 0 Pain Relevance 1.15
Thus, at doses of 30 micrograms/kg s.c., ICS 205-930 completely prevented the morphine-, nicotine- and ethanol-induced stimulation of DA release in the nucleus accumbens; doses of 15 micrograms/kg s.c. partially prevented the morphine-, nicotine- and ethanol-induced stimulation of DA release while doses of 7.5 micrograms/kg s.c. were ineffective.
Positive_regulation (stimulation) of DA in nucleus accumbens associated with nucleus accumbens, dopamine, nicotine and morphine
12) Confidence 0.37 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2767122 Disease Relevance 0 Pain Relevance 1.17
This phosphorylation/dephosphorylation status is closely coupled to DAT endocytic trafficking and interestingly PKC activation has been shown to decrease DAT activity through clathrin-mediated endocytosis [31,55], an event associated with an increase in DAT phosphorylation [52].
Positive_regulation (increase) of DAT associated with kinase c
13) Confidence 0.36 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.20
Next, to confirm that the selective increase in maximal DAT-mediated DA uptake resulted from DAT-CPE interaction, we tested whether a minigene (MG) encoding sequences of the DAT-CT could block these effects, since coexpressioin of CT tail peptide would act as a competitive inhibitor to the CPE-DAT interaction.
Positive_regulation (increase) of DAT-mediated in tail associated with dopamine
14) Confidence 0.36 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.25
The NGF-treated cells show an ~8-fold increase in DAT levels vs. untreated cells after just 2 days.
Positive_regulation (increase) of DAT
15) Confidence 0.34 Published 2006 Journal J Mol Signal Section Body Doc Link PMC1769494 Disease Relevance 0 Pain Relevance 0
We did not observe any increase in gpt MFs in the livers of 2,6-DAT–treated rats or in the kidneys of 2,4- or 2,6-DAT–treated rats (Fig. 3, Supplementary table 4).
Positive_regulation (increase) of DAT in livers
16) Confidence 0.31 Published 2010 Journal Toxicological Sciences Section Body Doc Link PMC2819973 Disease Relevance 0.28 Pain Relevance 0
We did not observe any increase in gpt MFs in the livers of 2,6-DAT–treated rats or in the kidneys of 2,4- or 2,6-DAT–treated rats (Fig. 3, Supplementary table 4).
Positive_regulation (increase) of DAT in livers
17) Confidence 0.31 Published 2010 Journal Toxicological Sciences Section Body Doc Link PMC2819973 Disease Relevance 0.34 Pain Relevance 0
Treatments with 2,4-DAT, but not 2,6-DAT, increased the relative weight of the livers and kidneys in a dose-dependent manner.
Positive_regulation (increased) of DAT in livers
18) Confidence 0.31 Published 2010 Journal Toxicological Sciences Section Body Doc Link PMC2819973 Disease Relevance 0.27 Pain Relevance 0
We speculate, therefore, that 2,4-DAT could be activated in vivo via the pathway described above and induce mostly guanine adducts in DNA.
Positive_regulation (activated) of DAT
19) Confidence 0.31 Published 2010 Journal Toxicological Sciences Section Body Doc Link PMC2819973 Disease Relevance 0.47 Pain Relevance 0.03
An immunoblot of DAT protein from NGF-treated cells detected an increase in DAT protein by day 4 of NGF treatment (Fig. 1A).
Positive_regulation (increase) of DAT protein
20) Confidence 0.28 Published 2006 Journal J Mol Signal Section Body Doc Link PMC1769494 Disease Relevance 0.07 Pain Relevance 0.08

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