INT28460

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Context Info
Confidence 0.36
First Reported 1989
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 0.24
Pain Relevance 2.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Slc6a3) plasma membrane (Slc6a3) transmembrane transport (Slc6a3)
Anatomy Link Frequency
plasma 2
nucleus accumbens 2
Slc6a3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 147 100.00 Very High Very High Very High
Nicotine 8 100.00 Very High Very High Very High
Morphine 8 100.00 Very High Very High Very High
Nucleus accumbens 9 99.14 Very High Very High Very High
antagonist 4 81.64 Quite High
monoamine 15 69.80 Quite High
Kinase C 45 45.68 Quite Low
Ventral tegmentum 3 38.20 Quite Low
cocaine 3 26.52 Quite Low
addiction 8 18.96 Low Low
Disease Link Frequency Relevance Heat
Stress 11 85.20 High High
Death 4 83.92 Quite High
Decapitation 1 49.20 Quite Low
Schizophrenia 3 19.68 Low Low
Drug Dependence 6 18.96 Low Low
Disease 9 18.32 Low Low
Neurological Disease 3 17.12 Low Low
Cognitive Disorder 4 14.28 Low Low
Obesity 7 5.00 Very Low Very Low Very Low
Body Weight 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conversely, Hic-5, a LIM domain containing protein, has also been shown to bind to the DAT-CT and inhibit DAT localization to the plasma membrane [17].
Negative_regulation (inhibit) of Localization (localization) of DAT in plasma
1) Confidence 0.36 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0.24 Pain Relevance 0.04
However, coexpression of the MG encoding the peptide DAT-CT583–620 significantly inhibited the increasing effects of DAT-mediated DA translocation by CPE.
Negative_regulation (inhibited) of Localization (translocation) of DAT-mediated associated with dopamine
2) Confidence 0.35 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.25
We have shown that this interaction leads to cell surface stabilization of DAT via reduced degradation, possibly through a reduction in DAT phosphorylation.
Spec (possibly) Negative_regulation (reduction) of Localization (stabilization) of DAT
3) Confidence 0.35 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.18
Thus, at doses of 30 micrograms/kg s.c., ICS 205-930 completely prevented the morphine-, nicotine- and ethanol-induced stimulation of DA release in the nucleus accumbens; doses of 15 micrograms/kg s.c. partially prevented the morphine-, nicotine- and ethanol-induced stimulation of DA release while doses of 7.5 micrograms/kg s.c. were ineffective.
Negative_regulation (prevented) of Localization (release) of DA in nucleus accumbens associated with nucleus accumbens, dopamine, nicotine and morphine
4) Confidence 0.28 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2767122 Disease Relevance 0 Pain Relevance 1.23
ICS 205-930 (15-30 micrograms/kg s.c.) failed to modify the basal output of DA and its metabolites, however, ICS 205-930 dose dependently reduced the stimulation of DA release by morphine, nicotine and ethanol.
Negative_regulation (reduced) of Localization (release) of DA associated with dopamine, nicotine and morphine
5) Confidence 0.28 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2767122 Disease Relevance 0 Pain Relevance 1.11
The membranes were blocked and then immunolabeled with antibodies against DAT (1?
Negative_regulation (antibodies) of Localization (immunolabeled) of DAT
6) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808335 Disease Relevance 0 Pain Relevance 0.10

General Comments

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