INT28461

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Context Info
Confidence 0.41
First Reported 1989
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 10
Disease Relevance 0
Pain Relevance 8.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Slc6a3) plasma membrane (Slc6a3) transmembrane transport (Slc6a3)
Anatomy Link Frequency
nucleus accumbens 6
DA neurons 4
Slc6a3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 177 100.00 Very High Very High Very High
Morphine 28 99.84 Very High Very High Very High
Nucleus accumbens 24 99.68 Very High Very High Very High
Nicotine 28 99.56 Very High Very High Very High
antagonist 14 81.16 Quite High
Kinase C 45 5.00 Very Low Very Low Very Low
Neuropeptide 6 5.00 Very Low Very Low Very Low
gABA 6 5.00 Very Low Very Low Very Low
Neurotransmitter 6 5.00 Very Low Very Low Very Low
addiction 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 9 5.00 Very Low Very Low Very Low
Stress 9 5.00 Very Low Very Low Very Low
Obesity 6 5.00 Very Low Very Low Very Low
Drug Dependence 6 5.00 Very Low Very Low Very Low
Sprains And Strains 3 5.00 Very Low Very Low Very Low
Neurological Disease 3 5.00 Very Low Very Low Very Low
Death 3 5.00 Very Low Very Low Very Low
Schizophrenia 3 5.00 Very Low Very Low Very Low
Cognitive Disorder 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, coexpression of the MG encoding the peptide DAT-CT583–620 significantly inhibited the increasing effects of DAT-mediated DA translocation by CPE.
Positive_regulation (increasing) of Localization (translocation) of DAT-mediated associated with dopamine
1) Confidence 0.41 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.25
In addition, CPE association could reduce the phosphorylation state of DAT on serine residues, potentially leading to reduced internalization, thus stabilizing plasmalemmal DAT localization.


Positive_regulation (stabilizing) of Localization (localization) of DAT
2) Confidence 0.38 Published 2009 Journal Mol Brain Section Abstract Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.14
In contrast, ICS 205-930 (up to 30 micrograms/kg s.c.) failed to affect the amphetamine-induced stimulation of DA release in the nucleus accumbens.
Positive_regulation (stimulation) of Localization (release) of DA in nucleus accumbens associated with nucleus accumbens and dopamine
3) Confidence 0.35 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2767122 Disease Relevance 0 Pain Relevance 1.16
Thus, at doses of 30 micrograms/kg s.c., ICS 205-930 completely prevented the morphine-, nicotine- and ethanol-induced stimulation of DA release in the nucleus accumbens; doses of 15 micrograms/kg s.c. partially prevented the morphine-, nicotine- and ethanol-induced stimulation of DA release while doses of 7.5 micrograms/kg s.c. were ineffective.
Positive_regulation (stimulation) of Localization (release) of DA in nucleus accumbens associated with nucleus accumbens, dopamine, nicotine and morphine
4) Confidence 0.35 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2767122 Disease Relevance 0 Pain Relevance 1.17
Functional changes caused by CPE could be attributed to enhanced DAT expression and subsequent increase in DAT cell surface localization, due to decreased DAT degradation.
Positive_regulation (increase) of Localization (localization) of DAT
5) Confidence 0.34 Published 2009 Journal Mol Brain Section Abstract Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.15
The results indicate that blockade of 5-HT3 receptors selectively prevents the stimulation of DA release induced by drugs known to stimulate the firing activity of DA neurons.
Positive_regulation (induced) of Localization (release) of DA in DA neurons associated with dopamine
6) Confidence 0.30 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2767122 Disease Relevance 0 Pain Relevance 0.95
Thus, at doses of 30 micrograms/kg s.c., ICS 205-930 completely prevented the morphine-, nicotine- and ethanol-induced stimulation of DA release in the nucleus accumbens; doses of 15 micrograms/kg s.c. partially prevented the morphine-, nicotine- and ethanol-induced stimulation of DA release while doses of 7.5 micrograms/kg s.c. were ineffective.
Positive_regulation (stimulation) of Localization (release) of DA in nucleus accumbens associated with nucleus accumbens, dopamine, nicotine and morphine
7) Confidence 0.30 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2767122 Disease Relevance 0 Pain Relevance 1.21
The inhibitory effects of ICS 205-930 (15 and 30 micrograms/kg s.c.) on the drug-induced stimulation of DA release could also be extended to the neuroleptic haloperidol (0.1 mg/kg s.c.).
Positive_regulation (stimulation) of Localization (release) of DA associated with dopamine
8) Confidence 0.30 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2767122 Disease Relevance 0 Pain Relevance 1.11
The results indicate that blockade of 5-HT3 receptors selectively prevents the stimulation of DA release induced by drugs known to stimulate the firing activity of DA neurons.
Positive_regulation (stimulation) of Localization (release) of DA in DA neurons associated with dopamine
9) Confidence 0.30 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2767122 Disease Relevance 0 Pain Relevance 1.01
ICS 205-930 (15-30 micrograms/kg s.c.) failed to modify the basal output of DA and its metabolites, however, ICS 205-930 dose dependently reduced the stimulation of DA release by morphine, nicotine and ethanol.
Positive_regulation (stimulation) of Localization (release) of DA associated with dopamine, nicotine and morphine
10) Confidence 0.30 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2767122 Disease Relevance 0 Pain Relevance 1.10

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