INT284668

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Context Info
Confidence 0.16
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.86
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (LRRK2) plasma membrane (LRRK2) intracellular (LRRK2)
GTPase activity (LRRK2) cytoplasm (LRRK2)
Anatomy Link Frequency
dopaminergic neurons 2
LRRK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 4 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Abeta 1 5.00 Very Low Very Low Very Low
Paracetamol 1 5.00 Very Low Very Low Very Low
Multiple sclerosis 1 5.00 Very Low Very Low Very Low
Dopamine 1 5.00 Very Low Very Low Very Low
Serotonin 1 5.00 Very Low Very Low Very Low
Calcium channel 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 72 99.98 Very High Very High Very High
Toxicity 64 99.12 Very High Very High Very High
Helminth Infection 72 92.24 High High
Disease 48 85.84 High High
Creutzfeldt Jakob Disease 2 70.56 Quite High
Kuru 1 70.08 Quite High
Neurodegenerative Disease 13 50.00 Quite Low
Scrapie 1 7.28 Low Low
Shock 6 6.40 Low Low
Sprains And Strains 19 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, transgenic LRRK2 expression also led to a preferential loss of dopaminergic neurons, with G2019S fPD LRRK2 being measurably more toxic than wild type LRRK2.
Positive_regulation (led) of Gene_expression (expression) of LRRK2 in dopaminergic neurons associated with targeted disruption
1) Confidence 0.16 Published 2009 Journal Mol Neurodegener Section Body Doc Link PMC2762972 Disease Relevance 0.86 Pain Relevance 0

General Comments

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