INT284670

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Context Info
Confidence 0.78
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.22
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (LRRK2) plasma membrane (LRRK2) intracellular (LRRK2)
GTPase activity (LRRK2) cytoplasm (LRRK2)
LRRK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 13 5.00 Very Low Very Low Very Low
Glutamate 10 5.00 Very Low Very Low Very Low
addiction 6 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
midbrain 2 5.00 Very Low Very Low Very Low
Multiple sclerosis 2 5.00 Very Low Very Low Very Low
Serotonin 2 5.00 Very Low Very Low Very Low
Catecholamine 2 5.00 Very Low Very Low Very Low
Calcium channel 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 184 99.00 Very High Very High Very High
Targeted Disruption 150 94.28 High High
Toxicity 135 88.08 High High
Parkinson's Disease 51 87.76 High High
Helminth Infection 144 85.04 High High
Neurodegenerative Disease 30 50.00 Quite Low
Creutzfeldt Jakob Disease 4 37.68 Quite Low
Kuru 2 37.20 Quite Low
Shock 13 24.56 Low Low
Motor Neuron Diseases 2 16.16 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Also DJ-1 and LRRK2 proteins were shown to be localized into the mitochondria (Canet-Aviles et al., 2004; West et al., 2005).
Localization (localized) of LRRK2
1) Confidence 0.78 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2890153 Disease Relevance 0.47 Pain Relevance 0
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common known cause of familial Parkinson's disease (fPD).
Localization (cause) of LRRK2 associated with disease
2) Confidence 0.23 Published 2009 Journal Mol Neurodegener Section Body Doc Link PMC2762972 Disease Relevance 0.87 Pain Relevance 0
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common known cause of familial Parkinson's disease (fPD).
Localization (cause) of leucine-rich repeat kinase 2 associated with disease
3) Confidence 0.23 Published 2009 Journal Mol Neurodegener Section Body Doc Link PMC2762972 Disease Relevance 0.88 Pain Relevance 0

General Comments

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