INT28468

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Context Info
Confidence 0.67
First Reported 1989
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 0.63
Pain Relevance 2.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

methyltransferase activity (Pnmt) cytoplasm (Pnmt)
Anatomy Link Frequency
chromaffin cells 4
Pnmt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
medulla 2 99.36 Very High Very High Very High
Clonidine 6 97.92 Very High Very High Very High
Morphine 10 96.48 Very High Very High Very High
5HT 6 89.80 High High
Serotonin 8 89.60 High High
Catecholamine 4 87.32 High High
Potency 1 84.28 Quite High
dexamethasone 1 82.32 Quite High
agonist 1 79.44 Quite High
antagonist 2 79.28 Quite High
Disease Link Frequency Relevance Heat
Stress 8 85.56 High High
Attention Deficit Hyperactivity Disorder 2 78.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vivo, PNMT and tyrosine hydroxylase (TH) mRNA levels increase in rat adrenal medulla after a single injection of clonidine.
Positive_regulation (increase) of Transcription (levels) of PNMT in adrenal medulla associated with medulla and clonidine
1) Confidence 0.67 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7643129 Disease Relevance 0 Pain Relevance 0.50
Adrenal phenylethanolamine N-methyl-transferase (PNMT) mRNA levels were increased 4 h after both the PH and laparotomy and declined within 24 h.
Positive_regulation (increased) of Transcription (levels) of PNMT
2) Confidence 0.67 Published 1999 Journal Endocr Regul Section Body Doc Link 10700082 Disease Relevance 0 Pain Relevance 0
Ether inhalation increased adrenal tyrosine hydroxylase (TH) and phenylethanolamine N-methyltransferase (PNMT) mRNA expression as well as adrenal epinephrine (E) concentration in control rats but not in prenatally morphine-exposed (PM) animals.
Positive_regulation (increased) of Transcription (expression) of PNMT associated with morphine
3) Confidence 0.67 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15896472 Disease Relevance 0.32 Pain Relevance 0.71
Ether inhalation increased adrenal tyrosine hydroxylase (TH) and phenylethanolamine N-methyltransferase (PNMT) mRNA expression as well as adrenal epinephrine (E) concentration in control rats but not in prenatally morphine-exposed (PM) animals.
Positive_regulation (increased) of Transcription (expression) of phenylethanolamine N-methyltransferase associated with morphine
4) Confidence 0.48 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15896472 Disease Relevance 0.32 Pain Relevance 0.71
Induction of phenylethanolamine N-methyltransferase mRNA expression by glucocorticoids in cultured bovine adrenal chromaffin cells.
Positive_regulation (Induction) of Transcription (expression) of phenylethanolamine N-methyltransferase in chromaffin cells
5) Confidence 0.17 Published 1989 Journal Eur. J. Pharmacol. Section Title Doc Link 2767137 Disease Relevance 0 Pain Relevance 0.12

General Comments

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