INT284686

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Context Info
Confidence 0.66
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.55
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Tspo) aging (Tspo) response to stress (Tspo)
Anatomy Link Frequency
microglia 4
brain 2
Tspo (Rattus norvegicus)
Pain Link Frequency Relevance Heat
positron emission tomography 156 98.16 Very High Very High Very High
imagery 27 93.92 High High
Central nervous system 9 93.56 High High
Inflammatory response 6 63.28 Quite High
Multiple sclerosis 6 52.24 Quite High
medulla 90 5.00 Very Low Very Low Very Low
agonist 18 5.00 Very Low Very Low Very Low
Hippocampus 15 5.00 Very Low Very Low Very Low
amygdala 9 5.00 Very Low Very Low Very Low
fifth nerve 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neurological Disease 33 87.76 High High
Injury 6 84.56 Quite High
Chronic Disease 3 71.16 Quite High
Death 6 70.36 Quite High
INFLAMMATION 12 62.92 Quite High
Disease 18 57.96 Quite High
Neurodegenerative Disease 9 56.16 Quite High
Herpes Simplex Encephalitis 123 54.56 Quite High
Stroke 6 53.60 Quite High
Demyelinating Disease 6 52.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of the TSPO is low in the healthy brain, but is highly upregulated in neuroinflammation.
Positive_regulation (upregulated) of Gene_expression (expression) of TSPO in brain
1) Confidence 0.66 Published 2009 Journal Mol Imaging Biol Section Body Doc Link PMC2763079 Disease Relevance 0.86 Pain Relevance 0.33
The activation of microglia cells is accompanied by an increased expression of the translocator protein (TSPO), an 18 kDa component of a heteromeric complex.
Positive_regulation (increased) of Gene_expression (expression) of TSPO in microglia
2) Confidence 0.66 Published 2009 Journal Mol Imaging Biol Section Body Doc Link PMC2763079 Disease Relevance 0.84 Pain Relevance 0.29
The activation of microglia cells is accompanied by an increased expression of the translocator protein (TSPO), an 18 kDa component of a heteromeric complex.
Positive_regulation (increased) of Gene_expression (expression) of translocator protein in microglia
3) Confidence 0.48 Published 2009 Journal Mol Imaging Biol Section Body Doc Link PMC2763079 Disease Relevance 0.84 Pain Relevance 0.29

General Comments

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