INT28469

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Context Info
Confidence 0.49
First Reported 1989
Last Reported 2003
Negated 0
Speculated 0
Reported most in Title
Documents 4
Total Number 4
Disease Relevance 0.73
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

methyltransferase activity (Pnmt) cytoplasm (Pnmt)
Anatomy Link Frequency
chromaffin cells 4
VLM 2
Pnmt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 3 99.80 Very High Very High Very High
cva 5 99.70 Very High Very High Very High
medulla 8 98.64 Very High Very High Very High
Potency 1 84.28 Quite High
dexamethasone 1 82.32 Quite High
antagonist 3 79.28 Quite High
Neuropeptide 1 78.48 Quite High
Neurotransmitter 2 75.44 Quite High
Clonidine 3 66.00 Quite High
Calcium channel 1 63.88 Quite High
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 4 99.70 Very High Very High Very High
Toxocariasis 5 98.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Agents used as controls were SKF29661, which is a selective peripheral PNMT inhibitor, SKF64139, a PNMT inhibitor that inhibits equally both alpha-2-adrenoceptor activity and PNMT, and yohimbine, an alpha-2-adrenoceptor inhibitor that does not inhibit PNMT.
Positive_regulation (peripheral) of Gene_expression (selective) of PNMT
1) Confidence 0.49 Published 1996 Journal Neuropsychobiology Section Abstract Doc Link 8904737 Disease Relevance 0 Pain Relevance 0.07
A 15% haemorrhage significantly induced expression of PNMT in the rostral C1 region and NPY in the caudal C1 and A1 regions but had no effect on ENK at any sites, suggesting a differential regulation on the expression of these three genes in the VLM.
Positive_regulation (induced) of Gene_expression (expression) of PNMT in VLM associated with medulla and cva
2) Confidence 0.49 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12782392 Disease Relevance 0.73 Pain Relevance 0.58
Histamine activates proenkephalin A mRNA but not phenylethanolamine N-methyltransferase mRNA expression in cultured bovine adrenal chromaffin cells.
Positive_regulation (activates) of Gene_expression (expression) of phenylethanolamine N-methyltransferase in chromaffin cells associated with enkephalin
3) Confidence 0.33 Published 1989 Journal Eur. J. Pharmacol. Section Title Doc Link 2767138 Disease Relevance 0 Pain Relevance 0.34
Induction of phenylethanolamine N-methyltransferase mRNA expression by glucocorticoids in cultured bovine adrenal chromaffin cells.
Positive_regulation (Induction) of Gene_expression (expression) of phenylethanolamine N-methyltransferase in chromaffin cells
4) Confidence 0.18 Published 1989 Journal Eur. J. Pharmacol. Section Title Doc Link 2767137 Disease Relevance 0 Pain Relevance 0.12

General Comments

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