INT2847

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Context Info
Confidence 0.49
First Reported 1979
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 1.09
Pain Relevance 1.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (Ache) extracellular space (Ache) extracellular region (Ache)
cell adhesion (Ache) Golgi apparatus (Ache) plasma membrane (Ache)
Anatomy Link Frequency
eye 4
myocardium 2
RBC 2
lung 2
Ache (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Action potential 9 95.28 Very High Very High Very High
tetrodotoxin 16 94.40 High High
Pain 1 77.20 Quite High
anesthesia 2 75.00 Quite High
Kinase C 1 68.64 Quite High
Central nervous system 15 5.00 Very Low Very Low Very Low
sodium channel 12 5.00 Very Low Very Low Very Low
Dopamine 12 5.00 Very Low Very Low Very Low
Neurotransmitter 5 5.00 Very Low Very Low Very Low
Substantia nigra 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 1 86.96 High High
Weight Gain 1 85.28 High High
Body Weight 2 85.08 High High
Clostridium Infection 1 82.08 Quite High
Drug Induced Neurotoxicity 81 81.32 Quite High
Stress 10 80.24 Quite High
Ganglion Cysts 3 77.28 Quite High
Pain 1 77.20 Quite High
Poisoning 25 65.08 Quite High
Toxicity 26 50.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These effects were abolished by atropine and were therefore mediated by ACh accumulated in the myocardium during AChE inhibition.
Positive_regulation (accumulated) of Negative_regulation (inhibition) of AChE in myocardium
1) Confidence 0.49 Published 2010 Journal Exp. Physiol. Section Abstract Doc Link 19767403 Disease Relevance 0.08 Pain Relevance 0.22
Rats given repeated daily injections were more sensitive to VX and needed only 1/10 of the concentration to reach a similar level of AChE inhibition, compared to animals exposed by the osmotic pump.
Positive_regulation (reach) of Negative_regulation (inhibition) of AChE
2) Confidence 0.47 Published 2008 Journal Toxicology Section Abstract Doc Link 18614271 Disease Relevance 0.55 Pain Relevance 0.08
These experiments show that uniocular injections result in a markedly decreased level of AChE activity in layer IV of the medial part of cortical area 17 contralateral to the injected eye.
Positive_regulation (result) of Negative_regulation (level) of AChE in eye
3) Confidence 0.47 Published 1989 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 2706772 Disease Relevance 0.06 Pain Relevance 0.54
These experiments show that uniocular injections result in a markedly decreased level of AChE activity in layer IV of the medial part of cortical area 17 contralateral to the injected eye.
Positive_regulation (result) of Negative_regulation (decreased) of AChE in eye
4) Confidence 0.47 Published 1989 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 2706772 Disease Relevance 0.06 Pain Relevance 0.54
The results suggest that anesthetic inhibition of acetylcholinesterase is mediated through the lipid bilayer.
Positive_regulation (mediated) of Negative_regulation (inhibition) of acetylcholinesterase
5) Confidence 0.37 Published 1979 Journal Boll. Soc. Ital. Biol. Sper. Section Abstract Doc Link 550881 Disease Relevance 0 Pain Relevance 0.07
All of the changes in gene expression induced by the two OPs were observed with doses, which did not induce biologically significant AChE inhibition [58,59].
Neg (not) Positive_regulation (induce) of Negative_regulation (inhibition) of AChE
6) Confidence 0.30 Published 2008 Journal Environ Health Section Body Doc Link PMC2577708 Disease Relevance 0.27 Pain Relevance 0.03
Dose-response curves were generated for RBC AChE inhibition as a function of percutaneous dose for each OP test material over time.
Positive_regulation (generated) of Negative_regulation (inhibition) of AChE in RBC
7) Confidence 0.13 Published 1991 Journal Toxicol. Lett. Section Abstract Doc Link 2003275 Disease Relevance 0 Pain Relevance 0.07
In the presence of physostigmine, an acetylcholinesterase inhibitor, the PAF-induced contractions of lung strips were modestly enhanced, consistent with release of endogenous acetylcholine.
Positive_regulation (enhanced) of Negative_regulation (inhibitor) of acetylcholinesterase in lung
8) Confidence 0.02 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3958964 Disease Relevance 0.08 Pain Relevance 0.09

General Comments

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