INT28478

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Context Info
Confidence 0.44
First Reported 1989
Last Reported 1999
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 0
Pain Relevance 1.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

methyltransferase activity (Pnmt) cytoplasm (Pnmt)
Anatomy Link Frequency
chromaffin cells 10
Pnmt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 18 99.56 Very High Very High Very High
Catecholamine 6 95.32 Very High Very High Very High
medulla 4 87.60 High High
antagonist 7 68.48 Quite High
agonist 3 68.32 Quite High
Nicotine 9 50.28 Quite High
Calcium channel 5 48.12 Quite Low
Neurotransmitter 3 32.44 Quite Low
Opioid 6 25.44 Quite Low
Enkephalin 3 25.00 Low Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study evaluates the ability of clonidine and related drugs to regulate expression of the gene for the epinephrine-synthesizing enzyme phenylethanolamine N-methyltransferase (PNMT) in the rat adrenal gland and in bovine adrenal chromaffin cell cultures.
Regulation (regulate) of Gene_expression (synthesizing) of PNMT in chromaffin cell associated with clonidine
1) Confidence 0.44 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7643129 Disease Relevance 0 Pain Relevance 0.39
This study evaluates the ability of clonidine and related drugs to regulate expression of the gene for the epinephrine-synthesizing enzyme phenylethanolamine N-methyltransferase (PNMT) in the rat adrenal gland and in bovine adrenal chromaffin cell cultures.
Regulation (regulate) of Gene_expression (expression) of phenylethanolamine N-methyltransferase in chromaffin cell associated with clonidine
2) Confidence 0.42 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7643129 Disease Relevance 0 Pain Relevance 0.39
We conclude that before birth, adrenaline synthesis may be suppressed by a novel direct, or indirect, inhibitory effect of glucocorticoids on PNMT mRNA expression.
Regulation (effect) of Gene_expression (expression) of PNMT mRNA
3) Confidence 0.26 Published 1999 Journal J. Neuroendocrinol. Section Abstract Doc Link 10444314 Disease Relevance 0 Pain Relevance 0.07
Regulation of phenylethanolamine N-methyltransferase gene expression by imidazoline receptors in adrenal chromaffin cells.
Regulation (Regulation) of Gene_expression (expression) of phenylethanolamine N-methyltransferase in chromaffin cells
4) Confidence 0.18 Published 1995 Journal J. Neurochem. Section Title Doc Link 7643129 Disease Relevance 0 Pain Relevance 0.42
The effects of histamine on the regulation of proenkephalin A (ProEnk A) and phenylethanolamine N-methyltransferase (PNMT) mRNA expression were examined in cultures of bovine adrenal chromaffin cells.
Spec (examined) Regulation (effects) of Gene_expression (expression) of phenylethanolamine N-methyltransferase in chromaffin cells
5) Confidence 0.18 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2767138 Disease Relevance 0 Pain Relevance 0.07
The effects of histamine on the regulation of proenkephalin A (ProEnk A) and phenylethanolamine N-methyltransferase (PNMT) mRNA expression were examined in cultures of bovine adrenal chromaffin cells.
Regulation (regulation) of Gene_expression (expression) of phenylethanolamine N-methyltransferase in chromaffin cells
6) Confidence 0.18 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2767138 Disease Relevance 0 Pain Relevance 0.07

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