INT2848

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Context Info
Confidence 0.70
First Reported 1979
Last Reported 2011
Negated 0
Speculated 2
Reported most in Body
Documents 23
Total Number 27
Disease Relevance 10.64
Pain Relevance 4.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ABCA1) small molecule metabolic process (ABCA1) Golgi apparatus (ABCA1)
ATPase activity (ABCA1) plasma membrane (ABCA1) intracellular (ABCA1)
Anatomy Link Frequency
reticulum 3
plasma 2
liver 2
stem cells 2
nerve 1
ABCA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 161 100.00 Very High Very High Very High
Neurotransmitter 7 99.98 Very High Very High Very High
potassium channel 1 98.76 Very High Very High Very High
cINOD 41 98.66 Very High Very High Very High
Calcium channel 2 97.64 Very High Very High Very High
chemokine 10 97.12 Very High Very High Very High
Bioavailability 3 96.72 Very High Very High Very High
cytokine 27 96.64 Very High Very High Very High
cocaine 39 96.28 Very High Very High Very High
Dopamine 12 94.84 High High
Disease Link Frequency Relevance Heat
Islet Cell Adenoma 174 98.86 Very High Very High Very High
Pancreatic Cancer 165 98.44 Very High Very High Very High
Adenocarcinoma 406 97.52 Very High Very High Very High
Atherosclerosis 24 97.40 Very High Very High Very High
Pancreatitis 56 97.32 Very High Very High Very High
Breast Cancer 31 95.68 Very High Very High Very High
Toxicity 17 90.60 High High
Cancer 368 87.84 High High
Immune System Diseases 4 87.56 High High
Pain 16 87.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
and immune complex-C1q complexes, diminish expression of both cholesterol 27-hydroxylase, an anti-atherogenic enzyme, and ATP-binding cassette transporter A1 (ABCA1), a protein that controls a cellular pathway for secretion of cholesterol for transport to the liver, in cells relevant to atherogenesis [10,11].
Localization (secretion) of ABCA1 in liver associated with atherosclerosis
1) Confidence 0.70 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860062 Disease Relevance 0.39 Pain Relevance 0.21
and immune complex-C1q complexes, diminish expression of both cholesterol 27-hydroxylase, an anti-atherogenic enzyme, and ATP-binding cassette transporter A1 (ABCA1), a protein that controls a cellular pathway for secretion of cholesterol for transport to the liver, in cells relevant to atherogenesis [10,11].
Localization (secretion) of transporter A1 in liver associated with atherosclerosis
2) Confidence 0.61 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860062 Disease Relevance 0.39 Pain Relevance 0.21
The UDP-glucuronosyltransferases (UGTs) are a superfamily of membrane-bound enzymes whose active site is localized inside the endoplasmic reticulum.
Localization (localized) of membrane-bound in reticulum
3) Confidence 0.29 Published 2000 Journal Drug Metab. Dispos. Section Abstract Doc Link 10772635 Disease Relevance 0 Pain Relevance 0.12
Plexin B1 is a member of the plexin receptor family for secreted and membrane-bound semaphorines guiding cell migration and exon extension [14].
Localization (secreted) of membrane-bound
4) Confidence 0.09 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2805671 Disease Relevance 0.11 Pain Relevance 0.05
These putative membrane/secreted protein encoding genes identified for pancreatic cancer and islet cell tumors were then examined using unsupervised hierarchical clustering in the context of a diverse collection of normal human tissues.
Spec (examined) Localization (secreted) of membrane associated with islet cell adenoma and pancreatic cancer
5) Confidence 0.09 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1824711 Disease Relevance 0.79 Pain Relevance 0
In addition, the identification of secretory and membrane proteins using computational algorithms or annotations derived from genome-wide empirical assessments of mRNA localization further enhance of our ability to identify likely candidates for diagnostic and therapeutic purposes.
Localization (secretory) of membrane
6) Confidence 0.08 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1824711 Disease Relevance 1.13 Pain Relevance 0
For the 107 genes identified by significance analysis of microarrays with high expression in islet cell tumors, 32 were classified using sequence analysis as encoding secretory or membrane proteins, and an additional 20 genes were identified using the empirically derived dataset.
Localization (secretory) of membrane associated with islet cell adenoma
7) Confidence 0.08 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1824711 Disease Relevance 0.69 Pain Relevance 0
As secretory or membrane proteins may be especially useful as diagnostic markers or therapeutic targets, each gene enriched in pancreatic cancer or islet cell tumors was further analyzed using algorithms to identify signal peptide or transmembrane domains.
Localization (secretory) of membrane associated with islet cell adenoma and pancreatic cancer
8) Confidence 0.08 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1824711 Disease Relevance 1.46 Pain Relevance 0.07
Of the 259 genes in the “Adeno” clusters, 126 were classified as secretory or membrane proteins by amino acid sequence analysis.
Localization (secretory) of membrane
9) Confidence 0.08 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1824711 Disease Relevance 1.27 Pain Relevance 0.03
The resultant set of putative secretory and membrane protein genes were able to distinctly cluster the pancreatic adenocarcinomas, islet cell tumors, and each of the normal tissues (Figure 4).
Localization (secretory) of membrane associated with adenocarcinoma and islet cell adenoma
10) Confidence 0.08 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1824711 Disease Relevance 0.76 Pain Relevance 0
It is generally accepted that the CD20 protein functions as a channel regulator of ion influx (Ernst et al 2005) and that this membrane-bound protein is specifically found on the membrane of B-cells but is not expressed on stem cells nor on terminally-differentiated plasma cells.
Localization (found) of membrane in stem cells
11) Confidence 0.07 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721296 Disease Relevance 0.85 Pain Relevance 0.28
It is generally accepted that the CD20 protein functions as a channel regulator of ion influx (Ernst et al 2005) and that this membrane-bound protein is specifically found on the membrane of B-cells but is not expressed on stem cells nor on terminally-differentiated plasma cells.
Localization (found) of membrane-bound in stem cells
12) Confidence 0.07 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721296 Disease Relevance 0.85 Pain Relevance 0.27
The potassium channel blocker, 4-aminopyridine (4-AP), stimulates neurotransmitter release via plasma membrane depolarization and subsequent activation of voltage-gated calcium channels.
Localization (release) of membrane in plasma associated with neurotransmitter, calcium channel and potassium channel
13) Confidence 0.05 Published 1994 Journal Neuroreport Section Abstract Doc Link 7919177 Disease Relevance 0.09 Pain Relevance 0.20
Release of the membrane-bound enzyme by sonication into a soluble form induces a loss of sensitivity to anesthetics.
Localization (Release) of membrane-bound
14) Confidence 0.04 Published 1979 Journal Boll. Soc. Ital. Biol. Sper. Section Abstract Doc Link 550881 Disease Relevance 0 Pain Relevance 0.07
When nerve fibers have invaded the dental mesenchyme, a complicated interplay of secreted and membrane-bound factors probably directs the nerve terminals to appropriate sites.
Localization (secreted) of membrane-bound in nerve
15) Confidence 0.04 Published 2007 Journal Physiol. Behav. Section Abstract Doc Link 17585959 Disease Relevance 0.30 Pain Relevance 0.33
In addition, membrane-bound MMPs are known to cleave and activate secreted MMPs, first described for the activation of MMP-2 by MMP-14 through interaction with TIMP-2 [30, 71].
Localization (secreted) of membrane associated with metalloproteinase
16) Confidence 0.04 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989751 Disease Relevance 0.19 Pain Relevance 0.49
L(20)GAALSGLCLLSALALL(36) is required for this unique membrane localization as a signal anchor [2].
Localization (localization) of membrane
17) Confidence 0.04 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989751 Disease Relevance 0.21 Pain Relevance 0.24
Like secreted MMPs, membrane-bound MMPs can cleave extracellular matrix (ECM) molecules, as well as chemokines, cytokines, and growth factors [40] (Table 1).
Localization (secreted) of membrane in ECM associated with chemokine, metalloproteinase and cytokine
18) Confidence 0.04 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989751 Disease Relevance 0 Pain Relevance 0.48
The UGTs are membrane-bound enzymes localized on the luminal surface of the endoplasmic reticulum [74].
Localization (localized) of membrane-bound in reticulum
19) Confidence 0.03 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0.06 Pain Relevance 0.29
Such an possible effect could explain a wide variety of biological effects of Indo, and possibly other NSAIDs and amphiphilic drugs, because membrane phase behavior determines localization, structure and function of membrane proteins.
Spec (determines) Localization (localization) of membrane associated with cinod
20) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2809093 Disease Relevance 0 Pain Relevance 0.19

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