INT28484

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Context Info
Confidence 0.43
First Reported 1989
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 4.96
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Cog1) Golgi apparatus (Cog1)
Anatomy Link Frequency
plasma 1
Cog1 (Mus musculus)
Pain Link Frequency Relevance Heat
beta blocker 2 100.00 Very High Very High Very High
Angina 4 91.96 High High
alcohol 4 91.40 High High
Restless leg syndrome 2 86.88 High High
psoriasis 63 85.68 High High
Percutaneous transluminal coronary angioplasty 1 75.00 Quite High
ischemia 11 61.04 Quite High
tolerance 1 55.88 Quite High
Inflammation 20 5.00 Very Low Very Low Very Low
Dopamine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 43 99.56 Very High Very High Very High
Stroke 4 98.96 Very High Very High Very High
Myocardial Infarction 9 98.80 Very High Very High Very High
Nicotine Addiction 3 98.80 Very High Very High Very High
Weight Gain 8 98.56 Very High Very High Very High
Diabetes Mellitus 5 98.44 Very High Very High Very High
Death 1 98.34 Very High Very High Very High
Hypertension 5 97.96 Very High Very High Very High
Peripheral Arterial Disease 6 97.64 Very High Very High Very High
Psoriasis 106 97.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To investigate the acute changes in plasma oxidized low-density lipoprotein before and immediately after coronary angioplasty, we studied 132 consecutive patients who successfully underwent this procedure.
Spec (investigate) Regulation (changes) of low-density lipoprotein in plasma
1) Confidence 0.43 Published 2001 Journal Am. J. Cardiol. Section Abstract Doc Link 11137843 Disease Relevance 0 Pain Relevance 0.12
Significantly lower median values of high density lipoprotein cholesterols (HDL-C) (P less than 0.01), and significantly higher median values of low density lipoprotein cholesterols (LDL-C) (P less than 0.05) were found in the PAD group.
Regulation (values) of low density lipoprotein associated with peripheral arterial disease and disorder of lipid metabolism
2) Confidence 0.06 Published 1989 Journal Eur J Vasc Surg Section Abstract Doc Link 2767255 Disease Relevance 1.17 Pain Relevance 0.21
Apolipoprotein E (ApoE) is a glycoprotein involved in the regulation of triglycerides and low-density lipoprotein (LDL) levels [67].
Regulation (regulation) of low-density lipoprotein associated with disorder of lipid metabolism
3) Confidence 0.04 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2914266 Disease Relevance 1.18 Pain Relevance 0.07
In univariate linear regression analysis Gensini score significantly correlated with serum concentrations of apolipoprotein AII (r=-0.3242, P<0.05) and creatinine (r=+0.3194, P<0.05), but not with serum concentrations of lipids (total, low- and high-density lipoprotein cholesterol, triglycerides), other apolipoproteins (apo B, apo AI), lipoprotein(a), autoantibodies to oxidatively modified low-density lipoprotein or age, weight and status of smoking, diabetes or hypertension.
Regulation (modified) of low-density lipoprotein associated with nicotine addiction, diabetes mellitus, hypertension and disorder of lipid metabolism
4) Confidence 0.04 Published 2000 Journal Ren Fail Section Abstract Doc Link 11104167 Disease Relevance 1.08 Pain Relevance 0.08
Effects of a cardioselective beta-blocker on postprandial triglyceride-rich lipoproteins, low density lipoprotein particle size and glucose-insulin homeostasis in middle-aged men with modestly increased cardiovascular risk.
Regulation (Effects) of low density lipoprotein associated with beta blocker
5) Confidence 0.03 Published 1998 Journal Atherosclerosis Section Title Doc Link 9622282 Disease Relevance 0.44 Pain Relevance 0.21
Ambulatory use of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase inhibitors, or statins, is known to reduce the risk of cardiovascular events including death, myocardial infarction, stroke, and renal function, in addition to their lowering effect on low-density lipoprotein (LDL) and total cholesterol levels [1].
Regulation (effect) of low-density lipoprotein associated with stroke, disorder of lipid metabolism, myocardial infarction and death
6) Confidence 0.01 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC2927584 Disease Relevance 0.61 Pain Relevance 0.03
There were no clinically relevant changes in mean fasting serum glucose, insulin or serum lipid levels (low density lipoprotein, high density lipoprotein, and triglycerides) or in renal function.
Neg (no) Regulation (changes) of low density lipoprotein
7) Confidence 0.01 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012441 Disease Relevance 0.48 Pain Relevance 0

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