INT28484

Context Info Confidence 0.43 First Reported 1989 Last Reported 2010 Negated 1 Speculated 1 Reported most in Body Documents 6 Total Number 7 Disease Relevance 4.96 Pain Relevance 0.71

transport (Cog1) Golgi apparatus (Cog1)

Anatomy Link Frequency plasma 1 Cog1 (Mus musculus)

Pain Link Frequency Relevance Heat beta blocker 2 100.00 Angina 4 91.96 alcohol 4 91.40 Restless leg syndrome 2 86.88 psoriasis 63 85.68 Percutaneous transluminal coronary angioplasty 1 75.00 ischemia 11 61.04 tolerance 1 55.88 Inflammation 20 5.00 Dopamine 6 5.00

Disease Link Frequency Relevance Heat Disorder Of Lipid Metabolism 43 99.56 Stroke 4 98.96 Myocardial Infarction 9 98.80 Nicotine Addiction 3 98.80 Weight Gain 8 98.56 Diabetes Mellitus 5 98.44 Death 1 98.34 Hypertension 5 97.96 Peripheral Arterial Disease 6 97.64 Psoriasis 106 97.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

To investigate the acute changes in plasma oxidized low-density lipoprotein before and immediately after coronary angioplasty, we studied 132 consecutive patients who successfully underwent this procedure.

Spec (investigate) Regulation (changes) of low-density lipoprotein in plasma

1) Confidence 0.43 Published 2001 Journal Am. J. Cardiol. Section Abstract Doc Link 11137843 Disease Relevance 0 Pain Relevance 0.12

Significantly lower median values of high density lipoprotein cholesterols (HDL-C) (P less than 0.01), and significantly higher median values of low density lipoprotein cholesterols (LDL-C) (P less than 0.05) were found in the PAD group.

Regulation (values) of low density lipoprotein associated with peripheral arterial disease and disorder of lipid metabolism

2) Confidence 0.06 Published 1989 Journal Eur J Vasc Surg Section Abstract Doc Link 2767255 Disease Relevance 1.17 Pain Relevance 0.21

Apolipoprotein E (ApoE) is a glycoprotein involved in the regulation of triglycerides and low-density lipoprotein (LDL) levels [67].

Regulation (regulation) of low-density lipoprotein associated with disorder of lipid metabolism

3) Confidence 0.04 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2914266 Disease Relevance 1.18 Pain Relevance 0.07

In univariate linear regression analysis Gensini score significantly correlated with serum concentrations of apolipoprotein AII (r=-0.3242, P<0.05) and creatinine (r=+0.3194, P<0.05), but not with serum concentrations of lipids (total, low- and high-density lipoprotein cholesterol, triglycerides), other apolipoproteins (apo B, apo AI), lipoprotein(a), autoantibodies to oxidatively modified low-density lipoprotein or age, weight and status of smoking, diabetes or hypertension.

Regulation (modified) of low-density lipoprotein associated with nicotine addiction, diabetes mellitus, hypertension and disorder of lipid metabolism

4) Confidence 0.04 Published 2000 Journal Ren Fail Section Abstract Doc Link 11104167 Disease Relevance 1.08 Pain Relevance 0.08

Effects of a cardioselective beta-blocker on postprandial triglyceride-rich lipoproteins, low density lipoprotein particle size and glucose-insulin homeostasis in middle-aged men with modestly increased cardiovascular risk.

Regulation (Effects) of low density lipoprotein associated with beta blocker

5) Confidence 0.03 Published 1998 Journal Atherosclerosis Section Title Doc Link 9622282 Disease Relevance 0.44 Pain Relevance 0.21

Ambulatory use of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase inhibitors, or statins, is known to reduce the risk of cardiovascular events including death, myocardial infarction, stroke, and renal function, in addition to their lowering effect on low-density lipoprotein (LDL) and total cholesterol levels [1].

Regulation (effect) of low-density lipoprotein associated with stroke, disorder of lipid metabolism, myocardial infarction and death

6) Confidence 0.01 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC2927584 Disease Relevance 0.61 Pain Relevance 0.03

There were no clinically relevant changes in mean fasting serum glucose, insulin or serum lipid levels (low density lipoprotein, high density lipoprotein, and triglycerides) or in renal function.

Neg (no) Regulation (changes) of low density lipoprotein

7) Confidence 0.01 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012441 Disease Relevance 0.48 Pain Relevance 0

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