INT284844

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Context Info
Confidence 0.59
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.18
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Nav1) cytoskeleton (Nav1) cytoplasm (Nav1)
Nav1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nav1.7 47 100.00 Very High Very High Very High
sodium channel 28 95.16 Very High Very High Very High
Pain 49 66.20 Quite High
tetrodotoxin 13 27.20 Quite Low
Analgesic 5 14.84 Low Low
addiction 6 5.00 Very Low Very Low Very Low
Action potential 5 5.00 Very Low Very Low Very Low
Congenital analgesia 3 5.00 Very Low Very Low Very Low
potassium channel 3 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 53 66.20 Quite High
Channelopathies 4 64.88 Quite High
Nociception 4 50.72 Quite High
Blindness 1 47.12 Quite Low
Erythermalgia 12 5.00 Very Low Very Low Very Low
Somatoform Disorder 10 5.00 Very Low Very Low Very Low
Targeted Disruption 8 5.00 Very Low Very Low Very Low
Injury 5 5.00 Very Low Very Low Very Low
Bites And Stings 3 5.00 Very Low Very Low Very Low
Polio 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To study the effect of these mutations on the cellular localization of Nav1.7, FLAG-tagged SCN9A constructs were generated.
Regulation (effect) of Localization (localization) of Nav1.7 associated with nav1.7
1) Confidence 0.59 Published 2010 Journal Human Mutation Section Body Doc Link PMC2966863 Disease Relevance 0.13 Pain Relevance 0.75
This may be explained by lack of other regulatory factors responsible for Pdzd2-mediated membrane translocation of NaV1.8.
Regulation (responsible) of Localization (translocation) of NaV1
2) Confidence 0.17 Published 2009 Journal Mol Cell Neurosci Section Body Doc Link PMC2764382 Disease Relevance 0.05 Pain Relevance 0.08

General Comments

This test has worked.

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