INT284844

Context Info Confidence 0.59 First Reported 2009 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.18 Pain Relevance 0.83

cell differentiation (Nav1) cytoskeleton (Nav1) cytoplasm (Nav1)

Nav1 (Mus musculus)

Pain Link Frequency Relevance Heat Nav1.7 47 100.00 sodium channel 28 95.16 Pain 49 66.20 tetrodotoxin 13 27.20 Analgesic 5 14.84 addiction 6 5.00 Action potential 5 5.00 Congenital analgesia 3 5.00 potassium channel 3 5.00 withdrawal 2 5.00

Disease Link Frequency Relevance Heat Pain 53 66.20 Channelopathies 4 64.88 Nociception 4 50.72 Blindness 1 47.12 Erythermalgia 12 5.00 Somatoform Disorder 10 5.00 Targeted Disruption 8 5.00 Injury 5 5.00 Bites And Stings 3 5.00 Polio 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

To study the effect of these mutations on the cellular localization of Nav1.7, FLAG-tagged SCN9A constructs were generated.

Regulation (effect) of Localization (localization) of Nav1.7 associated with nav1.7

1) Confidence 0.59 Published 2010 Journal Human Mutation Section Body Doc Link PMC2966863 Disease Relevance 0.13 Pain Relevance 0.75

This may be explained by lack of other regulatory factors responsible for Pdzd2-mediated membrane translocation of NaV1.8.

Regulation (responsible) of Localization (translocation) of NaV1

2) Confidence 0.17 Published 2009 Journal Mol Cell Neurosci Section Body Doc Link PMC2764382 Disease Relevance 0.05 Pain Relevance 0.08

General Comments

This test has worked.