INT284846

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Context Info
Confidence 0.46
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 12
Disease Relevance 2.25
Pain Relevance 2.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pdzd2) endoplasmic reticulum (Pdzd2) nucleus (Pdzd2)
cytoplasm (Pdzd2)
Anatomy Link Frequency
sensory neurons 1
Pdzd2 (Mus musculus)
Pain Link Frequency Relevance Heat
sodium channel 147 99.80 Very High Very High Very High
Action potential 6 88.24 High High
unmyelinated 12 84.48 Quite High
Pain 69 76.56 Quite High
Eae 6 74.88 Quite High
tetrodotoxin 126 68.60 Quite High
Analgesic 18 67.80 Quite High
Pain threshold 12 54.80 Quite High
withdrawal 18 35.12 Quite Low
ASIC 3 29.40 Quite Low
Disease Link Frequency Relevance Heat
Nociception 39 100.00 Very High Very High Very High
Targeted Disruption 78 90.68 High High
Pain 99 76.56 Quite High
Inflammatory Pain 12 74.88 Quite High
INFLAMMATION 12 5.00 Very Low Very Low Very Low
Neuropathic Pain 9 5.00 Very Low Very Low Very Low
Diabetic Neuropathy 3 5.00 Very Low Very Low Very Low
Nerve Compression Syndromes 3 5.00 Very Low Very Low Very Low
Herpes Simplex Virus 3 5.00 Very Low Very Low Very Low
Injury 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This suggests Pdzd2 may bind to the wide range of voltage-gated sodium channels.


Pdzd2 Binding (bind) of associated with sodium channel
1) Confidence 0.46 Published 2009 Journal Mol Cell Neurosci Section Body Doc Link PMC2764382 Disease Relevance 0.08 Pain Relevance 0.10
Pdzd2 is also shown to associate with ?
Pdzd2 Binding (associate) of
2) Confidence 0.46 Published 2009 Journal Mol Cell Neurosci Section Body Doc Link PMC2764382 Disease Relevance 0.15 Pain Relevance 0.12
Purified GST (Fig. 2A, lane 4) failed to pull-down HA-Pdzd2(C), demonstrating that HA-Pdzd2(C) binds specifically to the intracellular loop between domains 2 and 3 of NaV1.8.
Pdzd2 Binding (binds) of
3) Confidence 0.35 Published 2009 Journal Mol Cell Neurosci Section Body Doc Link PMC2764382 Disease Relevance 0.09 Pain Relevance 0.03
As recent findings revealed an essential role of NaV1.7 in nociception (Nassar et al., 2004; Cox et al., 2006; Fertleman et al., 2006; Lee et al., 2007; Zhang et al., 2007), we tested the binding ability of Pdzd2 to NaV1.7.
Pdzd2 Binding (binding) of associated with nociception
4) Confidence 0.35 Published 2009 Journal Mol Cell Neurosci Section Body Doc Link PMC2764382 Disease Relevance 0.10 Pain Relevance 0.08
Pdzd2 binds to NaV1.8 and NaV1.7
Pdzd2 Binding (binds) of
5) Confidence 0.34 Published 2009 Journal Mol Cell Neurosci Section Body Doc Link PMC2764382 Disease Relevance 0 Pain Relevance 0.07
In the present study, we show that Pdzd2 binds directly to the intracellular loop between domains 2 and 3 of NaV1.8.
Pdzd2 Binding (binds) of
6) Confidence 0.34 Published 2009 Journal Mol Cell Neurosci Section Body Doc Link PMC2764382 Disease Relevance 0 Pain Relevance 0.15
It is therefore plausible that Pdzd2 in large diameter sensory neurons may play an important role in nociception by binding to NaV1.7.
Pdzd2 Binding (binding) of in sensory neurons associated with nociception
7) Confidence 0.34 Published 2009 Journal Mol Cell Neurosci Section Body Doc Link PMC2764382 Disease Relevance 0.10 Pain Relevance 0.08
It is also possible that Pdzd2 binds the sodium channels via non-canonical sequence defined by their structural features (Harris and Lim 2001).
Pdzd2 Binding (binds) of associated with sodium channel
8) Confidence 0.34 Published 2009 Journal Mol Cell Neurosci Section Body Doc Link PMC2764382 Disease Relevance 0 Pain Relevance 0.05
PDZD2 has also been shown to bind NaV1.7 and, may bind to all voltage-gated sodium channels via conserved PDZ binding motifs [44,45].
PDZD2 Binding (bind) of associated with sodium channel
9) Confidence 0.32 Published 2010 Journal Neuroscience Letters Section Body Doc Link PMC2977848 Disease Relevance 0.57 Pain Relevance 0.43
Purified GST (Fig. 2A, lane 4) failed to pull-down HA-Pdzd2(C), demonstrating that HA-Pdzd2(C) binds specifically to the intracellular loop between domains 2 and 3 of NaV1.8.
Pdzd2 Binding (binds) of
10) Confidence 0.31 Published 2009 Journal Mol Cell Neurosci Section Body Doc Link PMC2764382 Disease Relevance 0.09 Pain Relevance 0.03
As both PDZD2 and syntrophin-associated serine/threonine kinase (SASTK) have been shown to bind this intracellular loop [30] (Fig. 1), interaction with these molecules may be linked to the trafficking and electrophysiological properties of NaV1.8.


PDZD2 Binding (bind) of
11) Confidence 0.24 Published 2010 Journal Neuroscience Letters Section Body Doc Link PMC2977848 Disease Relevance 0.49 Pain Relevance 0.45
PDZD2 has also been shown to bind NaV1.7 and, may bind to all voltage-gated sodium channels via conserved PDZ binding motifs [44,45].
PDZD2 Binding (bind) of associated with sodium channel
12) Confidence 0.24 Published 2010 Journal Neuroscience Letters Section Body Doc Link PMC2977848 Disease Relevance 0.58 Pain Relevance 0.44

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