INT284850

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.32
First Reported 2009
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.04
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (S100a10)
S100a10 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 13 99.20 Very High Very High Very High
Eae 2 96.96 Very High Very High Very High
withdrawal 2 92.04 High High
unmyelinated 4 85.48 High High
Action potential 2 83.76 Quite High
Pain threshold 2 82.36 Quite High
sodium channel 27 78.72 Quite High
nociceptor 1 43.60 Quite Low
tetrodotoxin 16 5.00 Very Low Very Low Very Low
Sciatic nerve 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 12 99.52 Very High Very High Very High
Pain 19 99.20 Very High Very High Very High
Inflammatory Pain 2 96.96 Very High Very High Very High
Nociception 7 85.96 High High
Neuropathic Pain 3 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low
Diabetic Neuropathy 1 5.00 Very Low Very Low Very Low
Nerve Compression Syndromes 1 5.00 Very Low Very Low Very Low
Herpes Simplex Virus 1 5.00 Very Low Very Low Very Low
Injury 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The absence of a pain phenotype could be explained by the up-regulation of p11 that occurs in these mice, which could mask PDZD2 effects by increasing the amount of membrane associated NaV1.8 [44].
Regulation (regulation) of p11 associated with pain
1) Confidence 0.32 Published 2010 Journal Neuroscience Letters Section Body Doc Link PMC2977848 Disease Relevance 0.71 Pain Relevance 0.55
Response to the noxious pressure is also not altered in the Pdzd2-deficient mice, inconsistent with the data observed in the NaV1.8 knockouts and the p11 and NaV1.7 knockout mice.
Neg (not) Regulation (altered) of p11 associated with targeted disruption
2) Confidence 0.21 Published 2009 Journal Mol Cell Neurosci Section Body Doc Link PMC2764382 Disease Relevance 0.32 Pain Relevance 0.13

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox