INT284852

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Context Info
Confidence 0.26
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.58
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (S100a10)
Anatomy Link Frequency
plasma 2
neurons 1
A11 1
S100a10 (Mus musculus)
Pain Link Frequency Relevance Heat
sodium channel 43 98.52 Very High Very High Very High
Analgesic 2 93.84 High High
tetrodotoxin 19 88.56 High High
unmyelinated 8 85.12 High High
Sciatic nerve 8 83.04 Quite High
ASIC 2 75.12 Quite High
Neuritis 1 73.12 Quite High
Pain 21 71.76 Quite High
IPN 1 63.12 Quite High
Central nervous system 2 54.88 Quite High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 89 99.06 Very High Very High Very High
Nociception 11 96.84 Very High Very High Very High
Targeted Disruption 21 94.56 High High
Neuritis 1 73.12 Quite High
Pain 31 71.76 Quite High
Inflammatory Pain 3 63.12 Quite High
Neuropathic Pain 6 51.20 Quite High
Cognitive Disorder 3 49.44 Quite Low
Dementia 6 5.00 Very Low Very Low Very Low
Motor Neuron Diseases 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
p11 directly binds to NaV1.8 and help its translocation to the plasma membrane. ?
p11 Binding (help) of in plasma
1) Confidence 0.26 Published 2010 Journal Neuroscience Letters Section Abstract Doc Link PMC2977848 Disease Relevance 0.16 Pain Relevance 0.22
Significantly, p11 binds only to NaV1.8 and not to the other sodium channel subtypes also expressed in nociceptive neurons, such as NaV1.7 and NaV1.9 [33].
p11 Binding (binds) of in neurons associated with nociception and sodium channel
2) Confidence 0.25 Published 2010 Journal Neuroscience Letters Section Body Doc Link PMC2977848 Disease Relevance 0.28 Pain Relevance 0.09
As we reported previously, p11 binds to NaV1.8 and promotes its translocation to the plasma membrane, producing functional channels (Okuse et al., 2002).
p11 Binding (binds) of in plasma
3) Confidence 0.19 Published 2009 Journal Mol Cell Neurosci Section Body Doc Link PMC2764382 Disease Relevance 0.40 Pain Relevance 0.40
oligomer levels in the brains of the 3×Tg-AD mice, we performed dot blot experiments using A11, an oligomeric-specific antibody that recognizes high molecular weight A?
A11 Binding (recognizes) of in A11 associated with alzheimer's dementia
4) Confidence 0.02 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2989316 Disease Relevance 0.73 Pain Relevance 0.07

General Comments

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