INT284855

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Context Info
Confidence 0.21
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 0.99
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Nav1) endoplasmic reticulum (S100a10) cytoskeleton (Nav1)
cytoplasm (Nav1)
Anatomy Link Frequency
plasma 3
neurons 1
S100a10 (Mus musculus)
Nav1 (Mus musculus)
Pain Link Frequency Relevance Heat
sodium channel 65 99.04 Very High Very High Very High
Analgesic 6 93.84 High High
tetrodotoxin 45 89.20 High High
unmyelinated 8 84.24 Quite High
Sciatic nerve 8 82.16 Quite High
ASIC 2 76.16 Quite High
Pain 31 71.76 Quite High
IPN 3 63.12 Quite High
Central nervous system 2 54.00 Quite High
Lasting pain 6 43.68 Quite Low
Disease Link Frequency Relevance Heat
Nociception 17 97.36 Very High Very High Very High
Targeted Disruption 31 94.56 High High
Pain 45 71.76 Quite High
Inflammatory Pain 5 63.12 Quite High
Neuropathic Pain 6 50.32 Quite High
INFLAMMATION 5 5.00 Very Low Very Low Very Low
Diabetic Neuropathy 2 5.00 Very Low Very Low Very Low
Nerve Compression Syndromes 2 5.00 Very Low Very Low Very Low
Herpes Simplex Virus 2 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
p11 directly binds to NaV1.8 and help its translocation to the plasma membrane. ?
p11 Binding (binds) of NaV1 in plasma
1) Confidence 0.21 Published 2010 Journal Neuroscience Letters Section Abstract Doc Link PMC2977848 Disease Relevance 0.16 Pain Relevance 0.22
Significantly, p11 binds only to NaV1.8 and not to the other sodium channel subtypes also expressed in nociceptive neurons, such as NaV1.7 and NaV1.9 [33].
p11 Binding (binds) of NaV1 in neurons associated with nociception and sodium channel
2) Confidence 0.16 Published 2010 Journal Neuroscience Letters Section Body Doc Link PMC2977848 Disease Relevance 0.28 Pain Relevance 0.09
We have previously reported that p11 binds to the amino terminus of NaV1.8 and promotes the translocation of NaV1.8 to the plasma membrane in CHO-SNS22, a CHO cell line stably transfected with rat NaV1.8 cDNA that expresses cytosolic NaV1.8 (Okuse et al., 2002).
p11 Binding (binds) of NaV1 in plasma
3) Confidence 0.15 Published 2009 Journal Mol Cell Neurosci Section Body Doc Link PMC2764382 Disease Relevance 0.07 Pain Relevance 0.09
As we reported previously, p11 binds to NaV1.8 and promotes its translocation to the plasma membrane, producing functional channels (Okuse et al., 2002).
p11 Binding (binds) of NaV1 in plasma
4) Confidence 0.14 Published 2009 Journal Mol Cell Neurosci Section Body Doc Link PMC2764382 Disease Relevance 0.40 Pain Relevance 0.41
Unlike p11 which binds exclusively to NaV1.8 among the voltage-gated sodium channels (Poon et al., 2004), Pdzd2 also binds to NaV1.7.
p11 Binding (binds) of NaV1 associated with sodium channel
5) Confidence 0.12 Published 2009 Journal Mol Cell Neurosci Section Body Doc Link PMC2764382 Disease Relevance 0.07 Pain Relevance 0.08

General Comments

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