INT284860

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Context Info
Confidence 0.29
First Reported 2009
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 9
Total Number 13
Disease Relevance 2.33
Pain Relevance 2.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Pdzd2, Nav1) cell differentiation (Nav1) extracellular region (Pdzd2)
endoplasmic reticulum (Pdzd2) cytoskeleton (Nav1) nucleus (Pdzd2)
Anatomy Link Frequency
sensory neurons 1
Pdzd2 (Mus musculus)
Nav1 (Mus musculus)
Pain Link Frequency Relevance Heat
sodium channel 163 100.00 Very High Very High Very High
Action potential 8 98.88 Very High Very High Very High
unmyelinated 16 97.00 Very High Very High Very High
Pain 77 93.04 High High
Eae 8 71.44 Quite High
tetrodotoxin 129 68.60 Quite High
Analgesic 18 67.80 Quite High
nav1.8 9 66.16 Quite High
ASIC 4 45.84 Quite Low
Pain threshold 13 44.40 Quite Low
Disease Link Frequency Relevance Heat
Nociception 43 100.00 Very High Very High Very High
Pain 111 93.04 High High
Targeted Disruption 83 92.16 High High
Inflammatory Pain 13 71.44 Quite High
INFLAMMATION 13 5.00 Very Low Very Low Very Low
Neuropathic Pain 12 5.00 Very Low Very Low Very Low
Diabetic Neuropathy 4 5.00 Very Low Very Low Very Low
Nerve Compression Syndromes 4 5.00 Very Low Very Low Very Low
Herpes Simplex Virus 4 5.00 Very Low Very Low Very Low
Injury 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is therefore plausible that Pdzd2 in large diameter sensory neurons may play an important role in nociception by binding to NaV1.7.
Pdzd2 Binding (binding) of NaV1 in sensory neurons associated with nociception
1) Confidence 0.29 Published 2009 Journal Mol Cell Neurosci Section Body Doc Link PMC2764382 Disease Relevance 0.10 Pain Relevance 0.08
The interaction between NaV1.8 and Pdzd2 in the myc-Pdzd2 transfected CHO-SNS22 cells was confirmed by co-immunoprecipitation (Fig. 3C).


Pdzd2 Binding (interaction) of NaV1
2) Confidence 0.25 Published 2009 Journal Mol Cell Neurosci Section Body Doc Link PMC2764382 Disease Relevance 0 Pain Relevance 0.12
These observations suggest that the interaction between Pdzd2 and NaV1.8 is essential for the functional expression of the channel.
Pdzd2 Binding (interaction) of NaV1
3) Confidence 0.25 Published 2009 Journal Mol Cell Neurosci Section Body Doc Link PMC2764382 Disease Relevance 0 Pain Relevance 0.10
To examine the binding of Pdzd2 to NaV1.8 in vitro, we performed GST pull-down assays using the haemagglutinin (HA)-tagged rat Pdzd2 C-terminal fragment (201aa), HA-Pdzd2(C), and the intracellular loop between domains 2 and 3 of rat NaV1.8 (amino acid positions 893 to 1148) fused to GST (glutathione S-transferase), GST-NaV1.8(III).
Pdzd2 Spec (examine) Binding (binding) of NaV1
4) Confidence 0.25 Published 2009 Journal Mol Cell Neurosci Section Body Doc Link PMC2764382 Disease Relevance 0.05 Pain Relevance 0.07
The binding of PDZD2 to NaV1.8 and NaV1.7 (which together underlie action potential generation and propagation in unmyelinated nociceptive fibres) suggests that PDZD2 may modulate cell excitability and ultimately pain thresholds.
PDZD2 Binding (binding) of NaV1 associated with nociception, pain, action potential and unmyelinated
5) Confidence 0.23 Published 2010 Journal Neuroscience Letters Section Body Doc Link PMC2977848 Disease Relevance 0.65 Pain Relevance 0.50
Unlike p11 which binds exclusively to NaV1.8 among the voltage-gated sodium channels (Poon et al., 2004), Pdzd2 also binds to NaV1.7.
Pdzd2 Binding (binds) of NaV1 associated with sodium channel
6) Confidence 0.22 Published 2009 Journal Mol Cell Neurosci Section Body Doc Link PMC2764382 Disease Relevance 0.08 Pain Relevance 0.08
Pdzd2 binds to NaV1.8 and NaV1.7
Pdzd2 Binding (binds) of NaV1
7) Confidence 0.22 Published 2009 Journal Mol Cell Neurosci Section Body Doc Link PMC2764382 Disease Relevance 0 Pain Relevance 0.07
Pdzd2 binds to NaV1.8 and NaV1.7
Pdzd2 Binding (binds) of NaV1
8) Confidence 0.22 Published 2009 Journal Mol Cell Neurosci Section Body Doc Link PMC2764382 Disease Relevance 0 Pain Relevance 0.07
In the present study, we show that Pdzd2 binds directly to the intracellular loop between domains 2 and 3 of NaV1.8.
Pdzd2 Binding (binds) of NaV1
9) Confidence 0.22 Published 2009 Journal Mol Cell Neurosci Section Body Doc Link PMC2764382 Disease Relevance 0 Pain Relevance 0.15
Unlike p11 which binds exclusively to NaV1.8 among the voltage-gated sodium channels (Poon et al., 2004), Pdzd2 also binds to NaV1.7.
Pdzd2 Binding (binds) of NaV1 associated with sodium channel
10) Confidence 0.22 Published 2009 Journal Mol Cell Neurosci Section Body Doc Link PMC2764382 Disease Relevance 0.08 Pain Relevance 0.08
PDZD2 has also been shown to bind NaV1.7 and, may bind to all voltage-gated sodium channels via conserved PDZ binding motifs [44,45].
PDZD2 Binding (bind) of NaV1 associated with sodium channel
11) Confidence 0.20 Published 2010 Journal Neuroscience Letters Section Body Doc Link PMC2977848 Disease Relevance 0.57 Pain Relevance 0.43
PDZD2 has been shown to directly bind the second intracellular loop of NaV1.8 (between domain II and III) through its C-terminus (Fig. 1).
PDZD2 Binding (bind) of NaV1
12) Confidence 0.20 Published 2010 Journal Neuroscience Letters Section Body Doc Link PMC2977848 Disease Relevance 0.14 Pain Relevance 0.09
The binding of PDZD2 to NaV1.8 and NaV1.7 (which together underlie action potential generation and propagation in unmyelinated nociceptive fibres) suggests that PDZD2 may modulate cell excitability and ultimately pain thresholds.
PDZD2 Binding (binding) of NaV1 associated with nociception, pain, action potential and unmyelinated
13) Confidence 0.18 Published 2010 Journal Neuroscience Letters Section Body Doc Link PMC2977848 Disease Relevance 0.65 Pain Relevance 0.50

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