INT284861

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Context Info
Confidence 0.17
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.07
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Nav1) endoplasmic reticulum (S100a10) cytoskeleton (Nav1)
cytoplasm (Nav1)
Anatomy Link Frequency
plasma 4
S100a10 (Mus musculus)
Nav1 (Mus musculus)
Pain Link Frequency Relevance Heat
sodium channel 22 95.88 Very High Very High Very High
tetrodotoxin 26 39.88 Quite Low
Analgesic 4 27.52 Quite Low
Pain 10 5.44 Low Low
withdrawal 4 5.00 Very Low Very Low Very Low
Acute pain 2 5.00 Very Low Very Low Very Low
Pain threshold 2 5.00 Very Low Very Low Very Low
Inflammatory stimuli 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
nav1.8 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nociception 6 72.28 Quite High
Targeted Disruption 14 13.08 Low Low
Pain 14 5.44 Low Low
Inflammatory Pain 2 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have previously reported that p11 binds to the amino terminus of NaV1.8 and promotes the translocation of NaV1.8 to the plasma membrane in CHO-SNS22, a CHO cell line stably transfected with rat NaV1.8 cDNA that expresses cytosolic NaV1.8 (Okuse et al., 2002).
p11 Positive_regulation (promotes) of Localization (translocation) of NaV1 in plasma
1) Confidence 0.17 Published 2009 Journal Mol Cell Neurosci Section Body Doc Link PMC2764382 Disease Relevance 0.07 Pain Relevance 0.09
In contrast to p11 which promotes the translocation of NaV1.8 to the plasma membrane in CHO cells (Okuse et al., 2002), Pdzd2 does not help the surface expression of NaV1.8 in CHO cells which suggests that Pdzd2 is a necessary but insufficient factor for NaV1.8 expression.
p11 Positive_regulation (promotes) of Localization (translocation) of NaV1 in plasma
2) Confidence 0.16 Published 2009 Journal Mol Cell Neurosci Section Body Doc Link PMC2764382 Disease Relevance 0 Pain Relevance 0.05

General Comments

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