INT284875

Context Info Confidence 0.53 First Reported 2008 Last Reported 2008 Negated 1 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.40 Pain Relevance 0

transport (Scn3b) plasma membrane (Scn3b)

Anatomy Link Frequency ventricles 1 Scn3b (Mus musculus)

Pain Link Frequency Relevance Heat Nav1.1 4 38.20 Action potential 52 5.00 addiction 10 5.00 action potential duration 10 5.00 Eae 6 5.00 sodium channel 2 5.00 Nav1.9 2 5.00

Disease Link Frequency Relevance Heat Body Weight 6 95.40 Arrhythmogenic Right Ventricular Dysplasia 26 92.48 Syndrome 8 77.88 Convulsion 2 70.04 Congenital Anomalies 4 64.56 Targeted Disruption 12 50.00 Adhesions 4 44.48 Cv Unclassified Under Development 4 32.80 Ventricular Tachycardia 44 24.88 Heart Arrhythmia 18 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

As expected, Scn3b mRNA was not expressed in Scn3b?

Neg (not) Transcription (not) of Scn3b

1) Confidence 0.53 Published 2008 Journal Prog Biophys Mol Biol Section Body Doc Link PMC2764399 Disease Relevance 0.07 Pain Relevance 0

Secondly, ventricles of such mice showed altered expression levels of Scn3b, Scn1b and Scn5a mRNA.

Transcription (levels) of Scn3b in ventricles

2) Confidence 0.53 Published 2008 Journal Prog Biophys Mol Biol Section Body Doc Link PMC2764399 Disease Relevance 0.33 Pain Relevance 0

General Comments

This test has worked.